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Correction pen as a hydrophobic/lipophobic barrier plotter integrated with paper-based chips and a mini UV-torch to implement all-in-one device for determination of carbazochrome
- Source :
- Analytica Chimica Acta. 1172:338684
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- The design of a cheap, simple, and handy sensing system for rapid quantitation of pharmaceuticals becomes mandatory to ease drug development procedures, quality control, health care, etc. This work describes a simple, innovative, and easily manufactured paper-based device using a correction pen as a plotter for hydrophobic/lipophobic barriers and graphene quantum dots for recognition and quantification of the hemostatic drug carbazochrome, via fluorescence turn-off mechanism mediated by the inner filter effect. A smartphone-based all-in-one device fitted with an inexpensive 365 nm flashlight as a UV light source and a free image processing software was developed for rapid and reliable interpretation of the fluorescence change from the paper-based device upon introduction of the drug. The simple and convenient steps permit the analysis of many samples in a very short time. The smartphone-based all-in-one device featured excellent sensitivity for carbazochrome with a limit of detection equals to 12 ng/detection zone and good %recovery (100.0 ± 0.4). The reliability of the device was ascertained by favorable statistical comparison with the analogous optimized conventional fluorimetry method and a reference HPLC method. The device has been successfully applied for versatile quantitation of carbazochrome in tablets and on manufacturing equipment surfaces with excellent recoveries. The device offers many green aspects that definitely assist the implementation of the sustainability concept to analytical laboratories. The cost-efficiency, reliability, and ease of fabrication as well as the greenness and user friendship qualify the device for wide application in low-income communities.
- Subjects :
- Ultraviolet Rays
Flashlight
02 engineering and technology
01 natural sciences
Biochemistry
Analytical Chemistry
Adrenochrome
Reliability (semiconductor)
Quantum Dots
Plotter
Environmental Chemistry
Carbazochrome
Hplc method
Spectroscopy
Chemistry
business.industry
010401 analytical chemistry
Reproducibility of Results
Paper based
021001 nanoscience & nanotechnology
0104 chemical sciences
Filter effect
Smartphone
0210 nano-technology
business
Sensitivity (electronics)
Computer hardware
Subjects
Details
- ISSN :
- 00032670
- Volume :
- 1172
- Database :
- OpenAIRE
- Journal :
- Analytica Chimica Acta
- Accession number :
- edsair.doi.dedup.....7aa00b7cf3287c28b2511e7733934108