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Glaucoma-Associated Long-term Mortality in a Rural Cohort from India: The Andhra Pradesh Eye Disease Study
- Source :
- Web of Science
-
Abstract
- AimTo evaluate glaucoma-associated mortality in a rural cohort in India.MethodsThe study cohort comprised individuals aged 40 years and above who took part in the Andhra Pradesh Eye Disease Study (APEDS1) during 1996–2000. All participants underwent detailed comprehensive eye examination. Glaucoma was defined using International Society of Geographic and Epidemiologic Ophthalmology criteria. This cohort was followed up after a decade (June 2009 to January 2010; APEDS2). Mortality HR analysis for ocular risk factors was performed using Cox proportional hazards regression after adjusting for sociodemographic, lifestyle and clinical variables.ResultsIn APEDS1, 2790 individuals aged more than or equal to 40 years were examined. 47.4% were male. Forty-five participants had primary open angle glaucoma (POAG) and 66 had primary angle closure disease (PACD). Ten years later, 1879 (67.3%) were available, 739 (26.5%) had died and 172 (6.2%) had migrated; whereas 22 of the 45 (48.8%) with POAG and 22 of the 66 (33.3%) with PACD had died. In univariate analysis, a higher mortality was associated with POAG (HR 1.9; 95% CI 1.23 to 2.94), pseudoexfoliation (HR 2.79; 95% CI 2.0 to 3.89), myopia (HR 1.78; 95% CI 1.54 to 2.06) and unit increase in cup:disc ratio (HR 4.49; 95% CI 2.64 to 7.64). In multivariable analysis, only cup:disc ratio remained independently associated with mortality (HR 2.5; 95% CI 1.3 to 5.1). The association remained significant when other ocular parameters were included in the model (HR 2.1; 95% CI 1.03 to 4.2).ConclusionsThis is the first longitudinal study to assess the association of glaucoma and mortality in a rural longitudinal cohort in India. Increased cup:disc ratio could be a potential marker for ageing and would need further validation.
- Subjects :
- Adult
Male
Rural Population
Longitudinal study
medicine.medical_specialty
Open angle glaucoma
genetic structures
Eye disease
Gonioscopy
India
Glaucoma
Disease
Slit Lamp Microscopy
Cohort Studies
Tonometry, Ocular
03 medical and health sciences
Cellular and Molecular Neuroscience
Age Distribution
0302 clinical medicine
Risk Factors
Internal medicine
Prevalence
medicine
Humans
Longitudinal Studies
Sex Distribution
Intraocular Pressure
Aged
Aged, 80 and over
Univariate analysis
business.industry
Middle Aged
medicine.disease
Sensory Systems
eye diseases
Ophthalmology
Cohort
030221 ophthalmology & optometry
Visual Field Tests
Female
Long term mortality
Visual Fields
Glaucoma, Angle-Closure
business
Glaucoma, Open-Angle
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 00071161
- Database :
- OpenAIRE
- Journal :
- Web of Science
- Accession number :
- edsair.doi.dedup.....7a9766cfebb79e531968b43fb3004e1f