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Evaluation of a Novel Glucose Area Under the Curve (AUC) Monitoring System: Comparison with the AUC by Continuous Glucose Monitoring
- Source :
- Diabetes & Metabolism Journal, Vol 40, Iss 4, Pp 326-333 (2016), Diabetes & Metabolism Journal
- Publication Year :
- 2016
- Publisher :
- Korean Diabetes Association, 2016.
-
Abstract
- Background Management of postprandial hyperglycemia is a key aspect in diabetes treatment. We developed a novel system to measure glucose area under the curve (AUC) using minimally invasive interstitial fluid extraction technology (MIET) for simple monitoring of postprandial glucose excursions. In this study, we evaluated the relationship between our system and continuous glucose monitoring (CGM) by comparing glucose AUC obtained using MIET with that obtained using CGM for a long duration. Methods Twenty diabetic inpatients wearing a CGM system were enrolled. For MIET measurement, a plastic microneedle array was applied to the skin as pretreatment, and hydrogels were placed on the pretreated area to collect interstitial fluid. Hydrogels were replaced every 2 or 4 hours and AUC was predicted on the basis of glucose and sodium ion levels. Results AUC predicted by MIET correlated well with that measured by CGM (r=0.93). Good performances of both consecutive 2- and 4-hour measurements were observed (measurement error: 11.7%±10.2% for 2 hours and 11.1%±7.9% for 4 hours), indicating the possibility of repetitive measurements up to 8 hours. The influence of neither glucose fluctuation nor average glucose level over the measurement accuracy was observed through 8 hours. Conclusion Our system showed good relationship with AUC values from CGM up to 8 hours, indicating that single pretreatment can cover a large portion of glucose excursion in a day. These results indicated possibility of our system to contribute to convenient monitoring of glucose excursions for a long duration.
- Subjects :
- Glucose area under the curve
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Extracellular fluid
03 medical and health sciences
0302 clinical medicine
Interstitial fluid
Diabetes mellitus
Glucose monitoring
Medicine
030212 general & internal medicine
Continuous glucose monitoring
lcsh:RC648-665
Postprandial glycemic excursion
business.industry
Area under the curve
Monitoring system
Glucose excursion
medicine.disease
Surgery
Postprandial
Others
Original Article
business
Biomedical engineering
Subjects
Details
- Language :
- English
- ISSN :
- 22336087 and 22336079
- Volume :
- 40
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Diabetes & Metabolism Journal
- Accession number :
- edsair.doi.dedup.....7a8980b25b54a53ce94a65055f146cf0