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STVNa Attenuates Isoproterenol-Induced Cardiac Hypertrophy Response through the HDAC4 and Prdx2/ROS/Trx1 Pathways
- Source :
- International Journal of Molecular Sciences, Vol 21, Iss 2, p 682 (2020), International Journal of Molecular Sciences, Volume 21, Issue 2
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Recent data show that cardiac hypertrophy contributes substantially to the overall heart failure burden. Mitochondrial dysfunction is a common feature of cardiac hypertrophy. Recent studies have reported that isosteviol inhibits myocardial ischemia-reperfusion injury in guinea pigs and H9c2 cells. This work investigated the protective mechanisms of isosteviol sodium (STVNa) against isoproterenol (Iso)-induced cardiac hypertrophy. We found that STVNa significantly inhibited H9c2 cell and rat primary cardiomyocyte cell surface, restored mitochondrial membrane potential (MMP) and morphological integrity, and decreased the expression of mitochondrial function-related proteins Fis1 and Drp1. Furthermore, STVNa decreased reactive oxygen species (ROS) levels and upregulated the expression of antioxidant factors, Thioredoxin 1 (Trx1) and Peroxiredoxin 2 (Prdx2). Moreover, STVNa restored the activity of histone deacetylase 4 (HDAC4) in the nucleus. Together, our data show that STVNa confers protection against Iso-induced myocardial hypertrophy primarily through the Prdx2/ROS/Trx1 signaling pathway. Thus, STVNA is a potentially effective treatment for cardiac hypertrophy in humans.
- Subjects :
- 0301 basic medicine
Pharmacology
Rats, Sprague-Dawley
lcsh:Chemistry
Thioredoxins
0302 clinical medicine
Myocytes, Cardiac
lcsh:QH301-705.5
Spectroscopy
chemistry.chemical_classification
Chemistry
cardiac hypertrophy
peroxiredoxin
General Medicine
Mitochondria
Computer Science Applications
Thioredoxin
Signal transduction
Diterpenes, Kaurane
Signal Transduction
FIS1
ros
Cardiomegaly
Peroxiredoxin 2
Article
Histone Deacetylases
Catalysis
Inorganic Chemistry
03 medical and health sciences
medicine
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
Heart Failure
Reactive oxygen species
isosteviol sodium
Myocardium
Organic Chemistry
Isoproterenol
Peroxiredoxins
thioredoxin
medicine.disease
HDAC4
Rats
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Heart failure
Reactive Oxygen Species
Peroxiredoxin
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 21
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....7a81c8fdaca50f841dd6fd158f0c19dc