Activation of Adenylate Cyclase by Choleragen

PERSPECTIVES AND SUMMARY S82 ROLE OF GANGLIOSIDE GMI AS THE CELL SURFACE RECEPTOR FOR CHOLERAGEN ......... ...... . . . ....... . ......... ...... .... 583 Interaction of Gangliosides and Their Oligosaccharides with Choleragen and Its Subunits 584 Activation of Adenylate Cyclase by Choleragen in Intact Cells 585 Activation of Adenylate Cyclase by Choleragen in Cell-Free Systems . 587 REQUIREMENTS FOR DEMONSTRATION OF ADENYLATE CYCLASE ACTIVATION BY CHOLERAGEN IN CELL-FREE SySTEMS ....... . .. 588 NAD !i88 GTP 588 Calcium-Dependent Regulatory Protein 589 ROLE OF NAD AS SUBSTRATE IN REACTIONS CATALYZED BY CHOLERAGEN 589 Mechanism of Action of NAD-Dependent Pseudomonas EXotoxin A and Diphtheria Toxin .... . . . ....... ..... ......... 590 NAD Glycohydrolase and ADP-Ribosyltransferase Activities oj Choleragen 591 Effects ofCholeragen on GTP-Binding Protein and GTPase Activity 592 SIMILARITIES BETWEEN CHOLERAGEN AND ESCHERICHIA COLI HEAT-LABILE ENTEROTOXIN 593 AN ADP-RIBOSYLTRANSFERASE FROM TURKEY ERYTHROCYTES WITH CHOLERAGEN-LIKE ACTIVITy .... . . . . . . . . . . . 595