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A New Grading System for Ototoxicity in Adults
- Source :
- Annals of otology, rhinology, and laryngology, 123(10), 711-718. Annals Publishing Company, Annals of Otology Rhinology and Laryngology, 123(10), 711-718. SAGE PUBLICATIONS INC
- Publication Year :
- 2014
-
Abstract
- Objective: This study aimed to propose an ototoxicity grading system sensitive to the effect of ototoxicity on specific daily life situations like speech intelligibility and the perception of ultra-high sounds and to test its feasibility compared to current criteria. Methods: Pure tone averages (PTAs) for speech perception (1-2-4 kHz) and ultra-high frequencies (8-10-12.5 kHz) were incorporated. Threshold shift and hearing level posttreatment were taken into account. Criteria were tested on head and neck cancer patients treated with (chemo-)radiotherapy ([C]RT) and compared with the Common Terminology Criteria for Adverse Events version 4 (CTCAEv4) and the American Speech-Language-Hearing Association criteria (ASHA). Results: Grades 1 and 2 were based on threshold shifts from baseline (in dB) and subjective complaints. Grades 3 and 4 were defined as treatment-induced hearing loss of ≥ 35 dB at PTA 1-2-4 kHz and ≥ 70 dB at PTA 1-2-4 kHz, respectively. In high-dose cisplatin CRT incidences by the new criteria, CTCAEv4 and ASHA were comparable (78%-88%). In RT and low-dose cisplatin CRT, incidences were 36% to 39% in the new criteria versus 22% to 53% in CTCAEv4 and ASHA. Conclusion: The new criteria show an increased sensitivity to ototoxicity compared to CTCAEv4 and ASHA and provide insight into the effect of hearing loss on certain daily life situations. The new grading system seems feasible for clinic and research purposes.
- Subjects :
- Adult
Male
medicine.medical_specialty
Speech perception
Hearing loss
Antineoplastic Agents
Audiology
Severity of Illness Index
Cohort Studies
Threshold shift
Ototoxicity
Predictive Value of Tests
medicine
otorhinolaryngologic diseases
Humans
Aged
hearing loss
Aged, 80 and over
business.industry
Pure tone
Auditory Threshold
Common Terminology Criteria for Adverse Events
Chemoradiotherapy
General Medicine
Middle Aged
medicine.disease
grading scales
ototoxicity
Otorhinolaryngology
Hearing level
Head and Neck Neoplasms
Speech Perception
Audiometry, Pure-Tone
Feasibility Studies
Female
Radiotherapy, Intensity-Modulated
Cisplatin
medicine.symptom
business
grading criteria
Subjects
Details
- Language :
- English
- ISSN :
- 00034894
- Database :
- OpenAIRE
- Journal :
- Annals of otology, rhinology, and laryngology, 123(10), 711-718. Annals Publishing Company, Annals of Otology Rhinology and Laryngology, 123(10), 711-718. SAGE PUBLICATIONS INC
- Accession number :
- edsair.doi.dedup.....7a78c731b0786a7cae3d98c15dece635