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Intravitreal Ziv-Aflibercept for Diabetic Macular Edema: 48-Week Outcomes
- Source :
- Ophthalmic surgery, lasersimaging retina. 49(4)
- Publication Year :
- 2017
-
Abstract
- BACKGROUND AND OBJECTIVE: To study the safety and efficacy of intravitreal injections of ziv-aflibercept (IVI-ZA) (Zaltrap; Sanofi-Aventis and Regeneron Pharmaceuticals, Tarrytown, NY) during a period of 48 weeks in patients with diabetic macular edema (DME). PATIENTS AND METHODS: Seven consecutive patients with DME were enrolled and submitted to 12 consecutive IVI-ZA with a 4-week interval. The safety parameters included changes in full-field electroretinogram (ERG) and systemic or ocular complications, and the efficacy parameters were the mean change from baseline in best-corrected visual acuity (BCVA) and central retinal thickness (CRT). RESULTS: No significant differences were found in any ERG component after IVI-ZA, and no systemic or ocular complication was observed. The improvement of BCVA was most significant after the first IVI-ZA and remained until week 48 ( P < .05). The CRT significantly decreased during the course of 48 weeks. CONCLUSION: The 48-week results are consistent with our previous 24-week findings, supporting IVI-ZA as a safe, efficient, and well-tolerated therapy for patients with DME. [ Ophthalmic Surg Lasers Imaging Retina . 2018;49:245–250.]
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Visual acuity
Time Factors
genetic structures
Recombinant Fusion Proteins
Diabetic macular edema
Visual Acuity
Macular Edema
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Ophthalmology
Electroretinography
Medicine
Humans
Macula Lutea
Prospective Studies
Prospective cohort study
Retina
Diabetic Retinopathy
medicine.diagnostic_test
Dose-Response Relationship, Drug
business.industry
Retinal
Middle Aged
eye diseases
Clinical trial
030104 developmental biology
medicine.anatomical_structure
Receptors, Vascular Endothelial Growth Factor
Treatment Outcome
chemistry
Intravitreal Injections
030221 ophthalmology & optometry
Female
sense organs
medicine.symptom
business
Erg
Tomography, Optical Coherence
Follow-Up Studies
Subjects
Details
- ISSN :
- 23258179
- Volume :
- 49
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Ophthalmic surgery, lasersimaging retina
- Accession number :
- edsair.doi.dedup.....7a4d3bc5e1a06320160ccf6aa5217f9a