High glucose levels induce membrane antioxidants, in terms of vitamin E and Coenzyme Q10, in children and adolescents with type 1 diabetes

Oxidative stress is defined as an imbalance between prooxidants and antioxidants in favor of the former (1), and diabetic patients are considered a risk group for increased oxidative stress (2,3). Studies regarding oxidant/antioxidant balance in type 1 diabetic children and adolescents have given conflicting results (4–7). The aim of this study was to determine whether serum hydroperoxides (reactive oxygen metabolites [ROMs]) as oxidative markers and plasma α-tocopherol (vitamin E) and coenzyme Q10 as indexes of antioxidant capacity could be related to metabolic control in 75 unselected children, adolescents, and young adults with type 1 diabetes. ROMs are the first markers of oxidation and one of the most reliable indicators of oxidative stress. Vitamin E is an important chain-breaking …