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Discovery of microbial natural products by activation of silent biosynthetic gene clusters
- Source :
- Nature Reviews Microbiology. 13:509-523
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Microorganisms produce a wealth of structurally diverse specialized metabolites with a remarkable range of biological activities and a wide variety of applications in medicine and agriculture, such as the treatment of infectious diseases and cancer, and the prevention of crop damage. Genomics has revealed that many microorganisms have far greater potential to produce specialized metabolites than was thought from classic bioactivity screens; however, realizing this potential has been hampered by the fact that many specialized metabolite biosynthetic gene clusters (BGCs) are not expressed in laboratory cultures. In this Review, we discuss the strategies that have been developed in bacteria and fungi to identify and induce the expression of such silent BGCs, and we briefly summarize methods for the isolation and structural characterization of their metabolic products.
- Subjects :
- Regulation of gene expression
Genetics
Biological Products
Bacteria
General Immunology and Microbiology
Metabolite
Microbial metabolism
Fungal genetics
Genomics
Gene Expression Regulation, Bacterial
Biology
biology.organism_classification
Microbiology
Bacterial genetics
chemistry.chemical_compound
Infectious Diseases
Bacterial Proteins
chemistry
Multigene Family
Silencer Elements, Transcriptional
Gene
Subjects
Details
- ISSN :
- 17401534 and 17401526
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Nature Reviews Microbiology
- Accession number :
- edsair.doi.dedup.....7a2dfa8f503cd22bee4398df9a5a82d2