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21-Gene recurrence score decreases receipt of chemotherapy in ER+ early-stage breast cancer: an analysis of the NCDB 2010–2013
- Source :
- Breast Cancer Research and Treatment
- Publication Year :
- 2016
- Publisher :
- Springer US, 2016.
-
Abstract
- The purpose of this study was to determine if receipt of chemotherapy was associated with utilization of the 21-gene recurrence score assay (RS assay) or with recurrence score (RS) in eligible patients. Using the National Cancer Data Base (NCDB), we identified female patients eligible for RS assay based on National Comprehensive Cancer Network (NCCN) guidelines: age 18–70, ER-positive and HER2-negative early-stage breast cancer diagnosed during 2010–2013. We excluded patients not meeting testing guidelines. Inclusion required result of RS in patients who underwent RS assay and status for receipt of chemotherapy. Multivariable logistic regression models and propensity matched analysis were used to determine associations between RS assay and RS with receipt of chemotherapy. Among 129,765 patients who were eligible, 74,778 underwent RS assay and had results available. Of these, 59.5 % (44,505) had low-risk, 32.0 % (23,920) had intermediate-risk, and 8.5 % (6353) had high-risk RS. Patients with intermediate- and high-risk RS were more likely to receive chemotherapy [OR 12.9 (CI 12.2–13.6), p
- Subjects :
- 0301 basic medicine
Oncology
Adult
Cancer Research
medicine.medical_specialty
Epidemiology
medicine.medical_treatment
Breast Neoplasms
NCDB
Logistic regression
03 medical and health sciences
Young Adult
0302 clinical medicine
Breast cancer
Drug Therapy
Internal medicine
medicine
Odds Ratio
Humans
Genetic Predisposition to Disease
Genetic Testing
Stage (cooking)
Aged
Neoplasm Staging
Receipt
Gynecology
Chemotherapy
medicine.diagnostic_test
business.industry
Cancer
Middle Aged
medicine.disease
Adjuvant chemotherapy
Oncotype Dx
030104 developmental biology
Logistic Models
Receptors, Estrogen
030220 oncology & carcinogenesis
21-Gene RS
Propensity score matching
Female
Oncotype DX
business
Subjects
Details
- Language :
- English
- ISSN :
- 15737217 and 01676806
- Volume :
- 159
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Breast Cancer Research and Treatment
- Accession number :
- edsair.doi.dedup.....7a23bd07bfb6c800cd62463e81ab8978