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Preparation and characterization of electrospun PLGA/gelatin nanofibers as a potential drug delivery system
- Source :
- Colloids and Surfaces B: Biointerfaces. 84:97-102
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Drug (Fenbufen, FBF)-loaded poly(d,l-lactide-co-glycolide) (PLGA) and PLGA/gelatin nanofibrous scaffolds were fabricated via electrospinning technique. The influences of gelatin content, fiber arrangement, crosslinking time and pH value of the buffer solution on FBF release behavior of the resulting nanofibrous scaffolds were investigated, with the corresponding FBF-loaded PLGA and PLGA/gelatin solvent-cast films as controls. The release rate of FBF was found to be increased with the increment of gelatin content for all the composite samples, and the FBF release rate of aligned nanofibrous scaffold was lower than that of randomly oriented scaffold. Moreover, the crosslinking treatment depressed effectively the burst release of FBF at initial release stage of PLGA/gelatin (9/1) nanofibrous scaffold. In addition, the pH value of the buffer solution could change the physical state of the polymer and affect the FBF release rate. © 2010 Elsevier B.V. All rights reserved.
- Subjects :
- Scaffold
food.ingredient
Nanofibers
macromolecular substances
Gelatin
chemistry.chemical_compound
Drug Delivery Systems
Colloid and Surface Chemistry
food
Polylactic Acid-Polyglycolic Acid Copolymer
medicine
Lactic Acid
Physical and Theoretical Chemistry
Fenbufen
technology, industry, and agriculture
Surfaces and Interfaces
General Medicine
Buffer solution
Phenylbutyrates
Electrospinning
body regions
PLGA
chemistry
Chemical engineering
Nanofiber
Drug delivery
Microscopy, Electron, Scanning
Polyglycolic Acid
Biotechnology
medicine.drug
Subjects
Details
- ISSN :
- 09277765
- Volume :
- 84
- Database :
- OpenAIRE
- Journal :
- Colloids and Surfaces B: Biointerfaces
- Accession number :
- edsair.doi.dedup.....7a1fcba0d1336b33dcb515599ea064c6