Enhanced ultrafiltration in rabbits with bicarbonate glycylglycine peritoneal dialysis solution

Objective The aim of the study was to investigate net ultrafiltration (NUF) with a new bicarbonate glycylglycine (BiGG) peritoneal dialysis solution compared to the standard lactate (La) solution. Design In six groups of 12 normal rabbits each we measured NUF after a 2-,4-, and 6–hour peritoneal dialysis with a BiGG solution (pH 7.35) and a standard La solution (pH 5.5) of similar glucose, electrolyte, and osmolality formulation. Furthermore, we studied the phosphatidylcholine concentration in the effluent of the two solutions. Results NUF volume was significantly greater with the BiGG rather than with the La solution by approximately 15% (pConclusion It is concluded that the BiGG solution, which has a stable pH, 7.35, due to the potent buffering capacity of bicarbonate and glycylglycine, enhances peritoneal NUF by maintaining a higher osmotic gradient and retarding lymphatic absorption through an increase in PC concentration in the peritoneal cavity.