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Melatonin and/or erythropoietin combined with hypothermia in a piglet model of perinatal asphyxia
- Source :
- Brain Communications
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- As therapeutic hypothermia is only partially protective for neonatal encephalopathy, safe and effective adjunct therapies are urgently needed. Melatonin and erythropoietin show promise as safe and effective neuroprotective therapies. We hypothesized that melatonin and erythropoietin individually augment 12-h hypothermia (double therapies) and hypothermia + melatonin + erythropoietin (triple therapy) leads to optimal brain protection. Following carotid artery occlusion and hypoxia, 49 male piglets (<br />As therapeutic hypothermia is partially protective in neonatal encephalopathy, adjunct therapies are required. In a piglet model of perinatal asphyxia, Pang et al. report that melatonin and erythropoietin are safe and individually augment cooling through different mechanisms. Staggered rather than concomitant dosing may be optimal for brain protection.<br />Graphical Abstract Graphical Abstract
- Subjects :
- melatonin
therapeutic hypothermia
Pharmacology
Neuroprotection
Melatonin
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Bolus (medicine)
030225 pediatrics
Medicine
Biological Psychiatry
AcademicSubjects/SCI01870
business.industry
Neonatal encephalopathy
neonatal encephalopathy
Hypoxia (medical)
Hypothermia
medicine.disease
Perinatal asphyxia
Psychiatry and Mental health
Neurology
Erythropoietin
Original Article
AcademicSubjects/MED00310
neuroprotection
erythropoietin
medicine.symptom
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 26321297
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Brain Communications
- Accession number :
- edsair.doi.dedup.....7a0f2f31ea84979c171d23b411590e07