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Metabolically labile cannabinoid esters: a 'soft drug' approach for the development of cannabinoid-based therapeutic drugs

Authors :
V. Di Marzo
G. Prota
Simone Bertini
Marco Macchia
I Carboni
Maria Grazia Cascio
Maria Digiacomo
Filippo Minutolo
T. Bisogno
Maurizio Bifulco
Minutolo, F
Cascio, Mg
Carboni, I
Bisogno, T
Prota, G
Bertini, S
Digiacomo, M
Bifulco, M.
DI MARZO, V
Macchia, M
Source :
Bioorganic & medicinal chemistry letters, 17 (2007): 4878–4881., info:cnr-pdr/source/autori:F. Minutolo, M.G. Cascio, I. Carboni, T. Bisogno, G. Prota, S. Bertini, M. Digiacomo, M. Bifulco, V. Di Marzo and M. Macchia/titolo:Metabolically labile cannabinoid esters: A 'soft drug' approach for the development of cannabinoid-based therapeutic drugs/doi:/rivista:Bioorganic & medicinal chemistry letters (Print)/anno:2007/pagina_da:4878/pagina_a:4881/intervallo_pagine:4878–4881/volume:17
Publication Year :
2007

Abstract

Biphenylic ester derivatives, designed by using a ‘soft-drug’ approach, proved to possess good binding properties toward cannabinoid CB1 and CB2 receptors and, at the same time, their metabolically labile ester portion would promote a rapid systemic inactivation. This may constitute a possible solution to the psychotropic side effects encountered when cannabinoids are therapeutically employed as local analgesic or antiglaucoma agents.

Details

Database :
OpenAIRE
Journal :
Bioorganic & medicinal chemistry letters, 17 (2007): 4878–4881., info:cnr-pdr/source/autori:F. Minutolo, M.G. Cascio, I. Carboni, T. Bisogno, G. Prota, S. Bertini, M. Digiacomo, M. Bifulco, V. Di Marzo and M. Macchia/titolo:Metabolically labile cannabinoid esters: A 'soft drug' approach for the development of cannabinoid-based therapeutic drugs/doi:/rivista:Bioorganic & medicinal chemistry letters (Print)/anno:2007/pagina_da:4878/pagina_a:4881/intervallo_pagine:4878–4881/volume:17
Accession number :
edsair.doi.dedup.....7a0f0f0064e5281f52f8fa2464c93135