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Intracoronary gene delivery of the cytoprotective factor vascular endothelial growth factor-B167 in canine patients with dilated cardiomyopathy: A short-term feasibility study
- Source :
- Veterinary Sciences, Volume 6, Issue 1, Veterinary Sciences, Vol 6, Iss 1, p 23 (2019)
- Publication Year :
- 2019
-
Abstract
- Dilated cardiomyopathy (DCM) is a myocardial disease of dogs and humans characterized by progressive ventricular dilation and depressed contractility and it is a frequent cause of heart failure. Conventional pharmacological therapy cannot reverse the progression of the disease and, in humans, cardiac transplantation remains the only option during the final stages of heart failure. Cytoprotective gene therapy with vascular endothelial growth factor-B167 (VEGF-B167) has proved an effective alternative therapy, halting the progression of the disease in experimental studies on dogs. The aim of this work was to test the tolerability and feasibility of intracoronary administration, under fluoroscopic guidance, of VEGF-B167 carried by adeno-associated viral vectors in canine DCM patients. Ten patients underwent the gene delivery procedure. The intraoperative phase was well tolerated by all dogs. Clinical and echocardiographic assessments at 7- and 30-days post-procedure showed stable conditions compared to the pre-procedure phase. The results of this work indicate that intracoronary VEGF-B167 gene delivery is feasible and tolerated in dogs with DCM. Further monitoring/investigations are ongoing to evaluate the effects of this therapy on disease progression.
- Subjects :
- medicine.medical_specialty
040301 veterinary sciences
Genetic enhancement
030204 cardiovascular system & hematology
Gene delivery
0403 veterinary science
Contractility
Clinical study
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Dogs
Internal medicine
medicine
Dog
lcsh:Veterinary medicine
General Veterinary
business.industry
Dilated cardiomyopathy
04 agricultural and veterinary sciences
medicine.disease
Intracoronary cytoprotective gene therapy
Transplantation
Vascular endothelial growth factor
Tolerability
chemistry
Heart failure
Cardiology
lcsh:SF600-1100
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Veterinary Sciences, Volume 6, Issue 1, Veterinary Sciences, Vol 6, Iss 1, p 23 (2019)
- Accession number :
- edsair.doi.dedup.....79f6c31a36e0d6dcdbea3aeec0140b13