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Head-activator and the neuroectodermal differentiation of P19 mouse embryonal carcinoma cells
- Source :
- Neuroscience letters. 207(1)
- Publication Year :
- 1996
-
Abstract
- P19 embryonal carcinoma cells differentiate into neuroectodermal derivates upon aggregation and treatment with retinoic acid (RA). Such RA-induced P19 cells, concomitant with neuronal differentiation, produce the neuropeptide head activator (HA) and release HA into the culture medium. The amount of HA produced by such differentiating P19 cells is more than 100-fold higher than that of uninduced P19 cells. RA-induced P19 cells respond to HA treatment with a two-fold increase in total number of neuronally differentiating P19 progeny. As early response to HA, an increase in intracellular calcium concentration is observed.
- Subjects :
- medicine.medical_specialty
Ratón
Retinoic acid
Neuropeptide
Fluorescent Antibody Technique
Tretinoin
Biology
Calcium in biology
Embryonal carcinoma
chemistry.chemical_compound
Mice
Internal medicine
medicine
Tumor Cells, Cultured
Animals
Activator (genetics)
General Neuroscience
Neuropeptides
Cell Differentiation
medicine.disease
Molecular biology
In vitro
Pyrrolidonecarboxylic Acid
Endocrinology
P19 cell
chemistry
embryonic structures
Calcium
Cell Division
Subjects
Details
- ISSN :
- 03043940
- Volume :
- 207
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Neuroscience letters
- Accession number :
- edsair.doi.dedup.....79ea0d6b6f3f20d95d79b095a9431604