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Prognostic and clinicopathological significance of long non-coding RNA in glioma
- Source :
- Neurosurgical Review. 43:1-8
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Growing evidence from recent studies have revealed that long non-coding RNA (lncRNA) might be a useful prognostic biomarker for glioma; we therefore conducted the current meta-analysis to evaluate prognostic and clinicopathological predictive value of lncRNA expression for glioma patients. Eligible studies were identified through multiple research strategies in PubMed, EMBASE, Web of Science, and Cochrane Library up to May 2017. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were utilized to calculate patient’s survival. Fourteen eligible studies with 1415 patients were ultimately included in this meta-analysis. Our meta-analysis showed a significant association between high lncRNA expression level and OS in glioma patients (HR 2.09, 95% CI 1.68–2.58, P
- Subjects :
- Oncology
medicine.medical_specialty
Subgroup analysis
Cochrane Library
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Glioma
Internal medicine
Biomarkers, Tumor
medicine
Humans
Tumor size
Brain Neoplasms
business.industry
Hazard ratio
General Medicine
Prognosis
medicine.disease
Confidence interval
Long non-coding RNA
Biomarker (medicine)
RNA, Long Noncoding
Surgery
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14372320 and 03445607
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Neurosurgical Review
- Accession number :
- edsair.doi.dedup.....79d1857368a0002100c44b76eb58e979