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Clinical and Immunological Features of 96 Moroccan Children with SCID Phenotype: Two Decades' Experience
- Source :
- Journal of clinical immunology. 41(3)
- Publication Year :
- 2020
-
Abstract
- Severe combined immunodeficiency (SCID) is a heterogeneous group of primary immunodeficiency diseases (PIDs) characterized by a lack of autologous T lymphocytes. This severe PID is rare, but has a higher prevalence in populations with high rates of consanguinity. The epidemiological, clinical, and immunological features of SCIDs in Moroccan patients have never been reported. The aim of this study was to provide a clinical and immunological description of SCID in Morocco and to assess changes in the care of SCID patients over time. This cross-sectional retrospective study included 96 Moroccan patients referred to the national PID reference center at Casablanca Children’s Hospital for SCID over two decades, from 1998 to 2019. The case definition for this study was age
- Subjects :
- Pediatrics
medicine.medical_specialty
Genotype
medicine.medical_treatment
Immunology
Inheritance Patterns
Consanguinity
Hematopoietic stem cell transplantation
Diagnosis, Differential
Epidemiology
medicine
Immunology and Allergy
Humans
Genetic Predisposition to Disease
Public Health Surveillance
Alleles
Severe combined immunodeficiency
business.industry
Disease Management
Retrospective cohort study
medicine.disease
Omenn syndrome
Morocco
Cross-Sectional Studies
Phenotype
Failure to thrive
Primary immunodeficiency
Severe Combined Immunodeficiency
Disease Susceptibility
medicine.symptom
business
Biomarkers
Subjects
Details
- ISSN :
- 15732592
- Volume :
- 41
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of clinical immunology
- Accession number :
- edsair.doi.dedup.....79bba91d3580c50fa17295ace8f43b2e