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Mediterranean diet adherence and rate of cerebral Aβ-amyloid accumulation: Data from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing
- Source :
- Translational Psychiatry, Vol 8, Iss 1, Pp 1-7 (2018), Translational Psychiatry
- Publication Year :
- 2018
- Publisher :
- Nature Publishing Group, 2018.
-
Abstract
- Accumulating research has linked Mediterranean diet (MeDi) adherence with slower cognitive decline and reduced Alzheimer’s disease (AD) risk. However, no study to-date has examined the relationship between MeDi adherence and accumulation of cerebral Aβ-amyloid (Aβ; a pathological hallmark of AD) in older adults. Cognitively normal healthy control participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Ageing completed the Cancer Council of Victoria Food Frequency Questionnaire at baseline, which was used to construct a MeDi score for each participant (score range 0–9; higher score indicating higher adherence). Cerebral Aβ load was quantified by Pittsburgh Compound B positron emission tomography at baseline, 18 and 36 months: Only individuals categorised as “Aβ accumulators”, and thus considered to be on the AD pathway, were included in the analysis (N = 77). The relationship between MeDi adherence, MeDi components, and change in cerebral Aβ load (baseline to 36 months) was evaluated using Generalised Linear Modelling, accounting for age, gender, education, Apolipoprotein E ε4 allele status, body mass index and total energy intake. Higher MeDi score was associated with less Aβ accumulation in our cohort (β = −0.01 ± 0.004, p = 0.0070). Of the individual MeDi score components, a high intake of fruit was associated with less accumulation of Aβ (β = −0.04 ± 0.01, p = 0.00036). Our results suggest MeDi adherence is associated with reduced cerebral AD pathology accumulation over time. When our results are considered collectively with previous data linking the MeDi to slower cognitive decline, it is apparent that MeDi adherence warrants further investigation in the quest to delay AD onset.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Aging
Mediterranean diet
Population
Diet, Mediterranean
Article
lcsh:RC321-571
03 medical and health sciences
Cellular and Molecular Neuroscience
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Medicine
Dementia
Humans
Cognitive decline
education
Cerebrum
Life Style
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Biological Psychiatry
Aged
2. Zero hunger
Aged, 80 and over
education.field_of_study
Amyloid beta-Peptides
business.industry
Australia
Middle Aged
medicine.disease
3. Good health
Psychiatry and Mental health
030104 developmental biology
chemistry
Ageing
Positron-Emission Tomography
Cohort
Female
business
Pittsburgh compound B
Body mass index
030217 neurology & neurosurgery
Biomarkers
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 21583188
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Translational Psychiatry
- Accession number :
- edsair.doi.dedup.....79ab0bd5ee204204e2c6922bff7aebe1