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Electroacupuncture at Quchi and Zusanli treats cerebral ischemia-reperfusion injury through activation of ERK signaling
- Source :
- Experimental and Therapeutic Medicine
- Publication Year :
- 2013
- Publisher :
- D.A. Spandidos, 2013.
-
Abstract
- The extracellular signal-regulated kinase (ERK) pathway, a critical mediator of cell proliferation, is activated in cerebral ischemia/reperfusion (I/R) injury and is therefore a key target in the treatment of ischemic stroke. Acupuncture has long been used in China to clinically treat stroke. However, the precise mechanism of its neuroprotective activities remains largely unknown. In the present study, a focal cerebral I/R-injured rat model was used to evaluate the in vivo therapeutic efficacy of electroacupuncture (EA) and investigate the underlying molecular mechanisms. EA significantly ameliorated neurological deficits and cerebral infarction in cerebral I/R-injured rats. Moreover, EA significantly increased the phosphorylation levels of ERK, as well as the protein expression levels of Ras, cyclin D1 and cyclin-dependent kinase (CDK)4. Consequently, EA-mediated activation of the ERK pathway resulted in the stimulation of cerebral cell proliferation. The present data suggest that EA at the Quchi and Zusanli acupoints exerts a neuroprotective effect in ischemic stroke via the activation of ERK signaling.
- Subjects :
- MAPK/ERK pathway
Cancer Research
Electroacupuncture
Cerebral infarction
business.industry
medicine.medical_treatment
Ischemia
General Medicine
Articles
Pharmacology
Zusanli
Quchi (LI11) and Zusanli (ST36) acupoints
medicine.disease
Neuroprotection
cerebral ischemia/reperfusion
cell proliferation
Immunology and Microbiology (miscellaneous)
electroacupuncture
medicine
business
extracellular signal-regulated kinase pathway
Reperfusion injury
Stroke
Subjects
Details
- Language :
- English
- ISSN :
- 17921015 and 17920981
- Volume :
- 5
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Experimental and Therapeutic Medicine
- Accession number :
- edsair.doi.dedup.....79a96e35d99e866559a43b2017c49a83