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Congenital malformations in 10,000 consecutive births in a university hospital: need for genetic counseling and prenatal diagnosis
- Source :
- The Journal of pediatrics. 104(3)
- Publication Year :
- 1984
-
Abstract
- Ten thousand children born consecutively in a university hospital were surveyed for the presence of major congenital malformations. About 2% (174) had a major congenital defect. Seventy-eight percent (135 of 174) of these malformations are associated with increased recurrence risk (greater than 1%), and 9% carry a high recurrence risk (greater than or equal to 10%). On the basis of the recurrence risk of 1% or higher and the feasibility of prenatal diagnosis, such a procedure should be considered in future pregnancies in 45% (79 of 174) of the mothers, especially inasmuch as 40% were primiparae younger than 36 years.
- Subjects :
- Chromosome Aberrations
Risk
Pediatrics
medicine.medical_specialty
business.industry
Genetic counseling
Infant, Newborn
Congenital malformations
Prenatal diagnosis
Chromosome Disorders
Genetic Counseling
University hospital
Recurrence risk
Congenital Abnormalities
Belgium
Pregnancy
Prenatal Diagnosis
Pediatrics, Perinatology and Child Health
Medicine
Humans
Female
business
Subjects
Details
- ISSN :
- 00223476
- Volume :
- 104
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The Journal of pediatrics
- Accession number :
- edsair.doi.dedup.....79a75204271c52613cde403592147b9c