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Synthesis of Taxane ABC Tricyclic Skeleton from Lycoctonine
- Source :
- Natural Product Communications. 7:1934578X1200700
- Publication Year :
- 2012
- Publisher :
- SAGE Publications, 2012.
-
Abstract
- A new conversional synthesis of the ABC ring system of taxoids from the C19-diterpenoid alkaloid lycoctonine was developed in 6 steps with 2% overall yield. The distinctive features of the conversion include pinacol rearrangement, enlargement of ring B, and opening of a four-membered ring.
- Subjects :
- Bridged-Ring Compounds
Pharmacology
chemistry.chemical_classification
Taxane
Molecular Structure
Stereochemistry
Aconitine
Plant Science
General Medicine
Pinacol rearrangement
Ring (chemistry)
Skeleton (computer programming)
Alkaloids
Complementary and alternative medicine
chemistry
Yield (chemistry)
Drug Discovery
Taxoids
Lycoctonine
Diterpenes
Tricyclic
Subjects
Details
- ISSN :
- 15559475 and 1934578X
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Natural Product Communications
- Accession number :
- edsair.doi.dedup.....7988ad95cdcfa022d208f7ab1d870d39
- Full Text :
- https://doi.org/10.1177/1934578x1200700603