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Elucidation of the role of the lamina cribrosa in glaucoma using optical coherence tomography
- Source :
- Survey of ophthalmology. 67(1)
- Publication Year :
- 2020
-
Abstract
- Glaucoma is a chronic and progressive optic neuropathy characterized by the death of retinal ganglion cells and corresponding visual field loss. Despite the growing number of studies on the subject, the pathogenesis of the disease remains unclear. Notwithstanding, several studies have shown that the lamina cribrosa (LC) is considered an anatomic site of glaucomatous optic nerve injury, thus having a key role in the pathophysiology of glaucoma development and progression. Different morphological alterations of the LC have been described in vivo in glaucomatous eyes after the evolution of optical coherence tomography (OCT) devices. The most relevant findings were the reduction of laminar thickness, the presence of localized defects, and the posterior LC displacement. These new laminar parameters documented through OCT are not only promising as possible additional tools for glaucoma diagnosis and monitoring, but also as predictors of disease progression. In spite of the advance of technology, however, proper evaluation of the LC is not yet viable in all eyes. We describe OCT-identified LC changes related to the development and progression of glaucoma and provide future directions based on a critical data analysis, focusing on its clinical relevance and applicability.
- Subjects :
- Retinal Ganglion Cells
medicine.medical_specialty
Lamina
genetic structures
Optic Disk
Glaucoma
Cribriform plate
Retinal ganglion
Optic neuropathy
03 medical and health sciences
0302 clinical medicine
Optical coherence tomography
Optic nerve injury
Ophthalmology
Optic Nerve Diseases
medicine
Humans
Intraocular Pressure
medicine.diagnostic_test
business.industry
medicine.disease
eye diseases
030221 ophthalmology & optometry
sense organs
Visual field loss
business
030217 neurology & neurosurgery
Tomography, Optical Coherence
Subjects
Details
- ISSN :
- 18793304
- Volume :
- 67
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Survey of ophthalmology
- Accession number :
- edsair.doi.dedup.....796f0f2baf0c058f4bbee77c6143bebd