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Interlesional Heterogeneity of Metastatic Neuroendocrine Tumors Based on 18F-DOPA PET/CT

Authors :
Aline M. van der Loo–van der Schaaf
Elisabeth G.E. de Vries
Adrienne H. Brouwers
Annemiek M E Walenkamp
Ronald Boellaard
Johannes H. van Snick
Lotte D de Hosson
Guided Treatment in Optimal Selected Cancer Patients (GUTS)
​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE)
Radiology and nuclear medicine
ACS - Heart failure & arrhythmias
Amsterdam Neuroscience - Brain Imaging
CCA - Imaging and biomarkers
Source :
de Hosson, L D, van der Loo-van der Schaaf, A M, Boellaard, R, van Snick, J H, de Vries, E G E, Brouwers, A H & Walenkamp, A M E 2019, ' Interlesional Heterogeneity of Metastatic Neuroendocrine Tumors Based on 18F-DOPA PET/CT ', Clinical Nuclear Medicine, vol. 44, no. 8, pp. 612-619 . https://doi.org/10.1097/RLU.0000000000002640, Clinical Nuclear Medicine, 44(8), 612-619. LIPPINCOTT WILLIAMS & WILKINS, Clinical Nuclear Medicine, 44(8), 612-619. Lippincott Williams and Wilkins
Publication Year :
2019

Abstract

Purpose Neuroendocrine tumors (NETs) can produce neuroendocrine amines resulting in symptoms. Selecting the most active amine-producing tumor lesions for local treatment might be beneficial for patients with metastatic small intestinal NET. Tumor burden correlates with catecholamine pathway activity. We analyzed interlesional heterogeneity with 18F-DOPA PET scans in patients with small intestinal NET and investigated if lesions with substantially higher 18F-DOPA uptake could be identified. Methods In this retrospective, observational study, the 18F-DOPA uptake was calculated by dividing SUVpeak of the lesion by the SUVmean of the background organ. The magnitude of heterogeneity between lesions within a patient was calculated by dividing the lesion with the highest by the one with the lowest 18F-DOPA uptake. Lesions with a higher 18F-DOPA uptake than the upper inner or outer fence (>1.5 or 3 times the interquartile range above the third quartile) were defined as lesions with mild or extreme high 18F-DOPA uptake, respectively, and presence of these was determined in patients with 10 lesions or more. Results 18F-DOPA was detected over 680 lesions in 38 patients, of which 35 were serotonin producing. 18F-DOPA uptake varied with a median of 8-fold up to 44-fold between lesions within a patient. In 12 of 20 evaluable patients, lesions with mild high 18F-DOPA uptake were found, and in 5, lesions with extreme high 18F-DOPA uptake. Conclusions 18F-DOPA-PET showed considerable heterogeneity in 18F-DOPA uptake between tumor lesions and identified lesions within patients with mild or extreme high 18F-DOPA uptake.

Details

Language :
English
ISSN :
03639762
Volume :
44
Issue :
8
Database :
OpenAIRE
Journal :
Clinical Nuclear Medicine
Accession number :
edsair.doi.dedup.....796d685ef35abe6252e3e9def1ca6936
Full Text :
https://doi.org/10.1097/RLU.0000000000002640