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Interlesional Heterogeneity of Metastatic Neuroendocrine Tumors Based on 18F-DOPA PET/CT
- Source :
- de Hosson, L D, van der Loo-van der Schaaf, A M, Boellaard, R, van Snick, J H, de Vries, E G E, Brouwers, A H & Walenkamp, A M E 2019, ' Interlesional Heterogeneity of Metastatic Neuroendocrine Tumors Based on 18F-DOPA PET/CT ', Clinical Nuclear Medicine, vol. 44, no. 8, pp. 612-619 . https://doi.org/10.1097/RLU.0000000000002640, Clinical Nuclear Medicine, 44(8), 612-619. LIPPINCOTT WILLIAMS & WILKINS, Clinical Nuclear Medicine, 44(8), 612-619. Lippincott Williams and Wilkins
- Publication Year :
- 2019
-
Abstract
- Purpose Neuroendocrine tumors (NETs) can produce neuroendocrine amines resulting in symptoms. Selecting the most active amine-producing tumor lesions for local treatment might be beneficial for patients with metastatic small intestinal NET. Tumor burden correlates with catecholamine pathway activity. We analyzed interlesional heterogeneity with 18F-DOPA PET scans in patients with small intestinal NET and investigated if lesions with substantially higher 18F-DOPA uptake could be identified. Methods In this retrospective, observational study, the 18F-DOPA uptake was calculated by dividing SUVpeak of the lesion by the SUVmean of the background organ. The magnitude of heterogeneity between lesions within a patient was calculated by dividing the lesion with the highest by the one with the lowest 18F-DOPA uptake. Lesions with a higher 18F-DOPA uptake than the upper inner or outer fence (>1.5 or 3 times the interquartile range above the third quartile) were defined as lesions with mild or extreme high 18F-DOPA uptake, respectively, and presence of these was determined in patients with 10 lesions or more. Results 18F-DOPA was detected over 680 lesions in 38 patients, of which 35 were serotonin producing. 18F-DOPA uptake varied with a median of 8-fold up to 44-fold between lesions within a patient. In 12 of 20 evaluable patients, lesions with mild high 18F-DOPA uptake were found, and in 5, lesions with extreme high 18F-DOPA uptake. Conclusions 18F-DOPA-PET showed considerable heterogeneity in 18F-DOPA uptake between tumor lesions and identified lesions within patients with mild or extreme high 18F-DOPA uptake.
- Subjects :
- Male
Fluorine Radioisotopes
F-18-DOPA PET scan
Carcinoid tumors
Tumor burden
Neuroendocrine tumors
GUIDELINES
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Positron Emission Tomography Computed Tomography
medicine
Humans
Radiology, Nuclear Medicine and imaging
Neoplasm Metastasis
Small Intestinal NET
Aged
Retrospective Studies
CARCINOID-TUMORS
PET-CT
business.industry
General Medicine
Middle Aged
medicine.disease
Dihydroxyphenylalanine
tracer uptake
18f dopa
Neuroendocrine Tumors
030220 oncology & carcinogenesis
LIVER-METASTASES
Catecholamine
Cancer research
Female
heterogeneity
business
Pathway activity
neuroendocrine tumor
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 03639762
- Volume :
- 44
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Clinical Nuclear Medicine
- Accession number :
- edsair.doi.dedup.....796d685ef35abe6252e3e9def1ca6936
- Full Text :
- https://doi.org/10.1097/RLU.0000000000002640