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Multiple Instances of Ancient Balancing Selection Shared Between Humans and Chimpanzees
- Source :
- Science, Science, American Association for the Advancement of Science, 2013, 339 (6127), pp.1578-1582. ⟨10.1126/science.1234070⟩, Science (New York, N.Y.), vol 339, iss 6127
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- Instances in which natural selection maintains genetic variation in a population over millions of years are thought to be extremely rare. We conducted a genome-wide scan for long-lived balancing selection by looking for combinations of SNPs shared between humans and chimpanzees. In addition to the major histocompatibility complex (MHC), we identified 125 regions in which the same haplotypes are segregating in the two species, all but two of which are non-coding. In six cases, there is evidence for an ancestral polymorphism that persisted to the present in humans and chimpanzees. Regions with shared haplotypes are significantly enriched for membrane glycoproteins, and a similar trend is seen among shared coding polymorphisms. These findings indicate that ancient balancing selection has shaped human variation and point to genes involved in host-pathogen interactions as common targets.
- Subjects :
- 0106 biological sciences
Pan troglodytes
General Science & Technology
Molecular Sequence Data
Population
Single-nucleotide polymorphism
Biology
Balancing selection
Major histocompatibility complex
Polymorphism, Single Nucleotide
010603 evolutionary biology
01 natural sciences
Article
03 medical and health sciences
Genetic
Clinical Research
Genetic variation
Genetics
Animals
Humans
Selection, Genetic
Polymorphism
education
Selection
Gene
Genetic Association Studies
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
0303 health sciences
education.field_of_study
Genome
Multidisciplinary
Natural selection
[SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE]
Base Sequence
Genome, Human
Human Genome
Haplotype
Single Nucleotide
Pedigree
Haplotypes
Host-Pathogen Interactions
biology.protein
Human
Subjects
Details
- Language :
- English
- ISSN :
- 00368075 and 10959203
- Database :
- OpenAIRE
- Journal :
- Science, Science, American Association for the Advancement of Science, 2013, 339 (6127), pp.1578-1582. ⟨10.1126/science.1234070⟩, Science (New York, N.Y.), vol 339, iss 6127
- Accession number :
- edsair.doi.dedup.....795cb215dfd3c8eb0b46c1f603f7ee70