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The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8+ T cell responses
- Source :
- Virology. :34-48
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- It is unclear if HIV-1 variants lose the ability to prime naive CD8 + cytotoxic T lymphocytes (CTL) during progressive, untreated infection. We conducted a comprehensive longitudinal analysis of viral evolution and its impact on primary and memory CD8 + T cell responses pre-seroconversion (SC), post-SC, and during combination antiretroviral therapy (cART). Memory T cell responses targeting autologous virus variants reached a nadir by 8 years post-SC with development of AIDS, followed by a transient enhancement of anti-HIV-1 CTL responses upon initiation of cART. We show broad and high magnitude primary T cell responses to late variants in pre-SC T cells, comparable to primary anti-HIV-1 responses induced in T cells from uninfected persons. Despite evolutionary changes, CD8 + T cells could still be primed to HIV-1 variants. Hence, vaccination against late, mutated epitopes could be successful in enhancing primary reactivity of T cells for control of the residual reservoir of HIV-1 during cART.
- Subjects :
- Adult
Male
Anti-HIV Agents
T-Lymphocytes
T cell
Epitopes, T-Lymphocyte
HIV Infections
cART
CD8-Positive T-Lymphocytes
Biology
Article
Epitope
Virus
Cohort Studies
Evolution, Molecular
Viral Proteins
03 medical and health sciences
Interleukin 21
0302 clinical medicine
Virology
Autologous viral variants
medicine
Humans
Cytotoxic T cell
Primary T cell responses
030304 developmental biology
Memory T cell responses
0303 health sciences
Histocompatibility Antigens Class I
virus diseases
3. Good health
CTL
medicine.anatomical_structure
Immunology
HIV-1
Memory T cell
CD8
030215 immunology
Subjects
Details
- ISSN :
- 00426822
- Database :
- OpenAIRE
- Journal :
- Virology
- Accession number :
- edsair.doi.dedup.....79533925e49e6a9b90ba263361e96d9d