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Lipid peroxidation in chronic gastritis; any influence of Helicobacter pylori?
- Source :
- Prostaglandins, leukotrienes, and essential fatty acids. 68(4)
- Publication Year :
- 2003
-
Abstract
- In an attempt to investigate the significance of lipid peroxidation in the pathogenesis of gastritis associated with or without Helicobacter pylori infection, malonodialdehyde (MDA) levels were measured by the thiobarbiturate assay in the gastric juice of 101 patients undergoing upper GI endoscopy and correlated with histopathological findings. Elevated MDA levels were found in all patients with gastritis compared with controls. MDA levels were significantly correlated with the extent of the mucosal inflammation and with disease activity in patients with reactive gastritis. In patients with H. pylori associated gastritis MDA levels were not correlated with disease activity but rather with the degree of atrophy. In this case, MDA levels were equal or even less than in patients with reactive gastritis. MDA levels were not affected by the history of consumption of PPIs, of H(2)-blockers or of NSAIDs over the last month before the endoscopy. It is concluded that lipid peroxidation is a mechanism involved in the pathogenesis of gastritis associated or not to H. pylori infection.
- Subjects :
- Male
medicine.medical_specialty
Free Radicals
Neutrophils
Spirillaceae
Clinical Biochemistry
Chronic gastritis
Gastroenterology
Thiobarbituric Acid Reactive Substances
Pathogenesis
Lipid peroxidation
chemistry.chemical_compound
Atrophy
Internal medicine
Malondialdehyde
Medicine
Humans
skin and connective tissue diseases
Aged
Inflammation
Gastric Juice
Mucous Membrane
biology
Helicobacter pylori
business.industry
Lipid metabolism
Cell Biology
Middle Aged
medicine.disease
biology.organism_classification
Lipid Metabolism
chemistry
Gastritis
Chronic Disease
Multivariate Analysis
Female
Lipid Peroxidation
medicine.symptom
business
Subjects
Details
- ISSN :
- 09523278
- Volume :
- 68
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Prostaglandins, leukotrienes, and essential fatty acids
- Accession number :
- edsair.doi.dedup.....7950cd5352472d8195ca9f618727db44