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Benzodiazepine inhibitors of the MMPs and TACE. Part 2
- Source :
- Bioorganic & Medicinal Chemistry Letters. 14:4147-4151
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- A series of benzodiazepine MMP/TACE inhibitors bearing polar moieties has been synthesized in an effort to optimize inhibitory activity against LPS-stimulated TNF production in human monocytes and oral activity in a murine LPS model.
- Subjects :
- Lipopolysaccharides
Lipopolysaccharide
medicine.drug_class
medicine.medical_treatment
Clinical Biochemistry
Pharmaceutical Science
Inflammation
ADAM17 Protein
Matrix Metalloproteinase Inhibitors
Matrix metalloproteinase
Pharmacology
Biochemistry
Monocytes
Cell Line
Benzodiazepines
Mice
chemistry.chemical_compound
Drug Discovery
medicine
Animals
Humans
Enzyme Inhibitors
Molecular Biology
Mice, Inbred BALB C
Mouth
Benzodiazepine
biology
Tumor Necrosis Factor-alpha
Monocyte
Organic Chemistry
Metalloendopeptidases
In vitro
ADAM Proteins
medicine.anatomical_structure
Cytokine
chemistry
Enzyme inhibitor
biology.protein
Molecular Medicine
lipids (amino acids, peptides, and proteins)
medicine.symptom
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....794b0d59bead1b7ef67297cd05f85d49
- Full Text :
- https://doi.org/10.1016/j.bmcl.2004.06.031