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Longitudinal Motor Functional Outcomes and Magnetic Resonance Imaging Patterns of Muscle Involvement in Upper Limbs in Duchenne Muscular Dystrophy

Authors :
Giorgia Coratti
Giorgia Petracca
Giulia Norcia
Fabrizia Chieppa
Nicola Forcina
Claudia Brogna
Lavinia Fanelli
Tommaso Tartaglione
Roberta Ruiz
Marika Pane
Eugenio Mercuri
Cesare Colosimo
Tommaso Verdolotti
Lara Cristiano
Luana Ficociello
Source :
Medicina, Volume 57, Issue 11, Medicina, Vol 57, Iss 1267, p 1267 (2021)
Publication Year :
2021

Abstract

Background and Objectives: The aim of this study was to evaluate longitudinal changes using both upper limb muscle Magnetic Resonance Imaging (MRI) at shoulder, arm and forearm levels and Performance of upper limb (PUL) in ambulant and non-ambulant Duchenne Muscular Dystrophy (DMD) patients. We also wished to define whether baseline muscle MRI could help to predict functional changes after one year. Materials and Methods: Twenty-seven patients had both baseline and 12month muscle MRI and PUL assessments one year later. Results: Ten were ambulant (age range 5–16 years), and 17 non ambulant (age range 10–30 years). Increased abnormalities equal or more than 1.5 point on muscle MRI at follow up were found on all domains: at shoulder level 12/27 patients (44%), at arm level 4/27 (15%) and at forearm level 6/27 (22%). Lower follow up PUL score were found in 8/27 patients (30%) at shoulder level, in 9/27 patients (33%) at mid-level whereas no functional changes were found at distal level. There was no constant association between baseline MRI scores and follow up PUL scores at arm and forearm levels but at shoulder level patients with moderate impairment on the baseline MRI scores between 16 and 34 had the highest risk of decreased function on PUL over a year. Conclusions: Our results confirmed that the integrated use of functional scales and imaging can help to monitor functional and MRI changes over time.

Details

ISSN :
16489144
Volume :
57
Issue :
11
Database :
OpenAIRE
Journal :
Medicina (Kaunas, Lithuania)
Accession number :
edsair.doi.dedup.....7945e6d434aad57933903edefc726b90