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Metabolic Syndrome Exacerbates the Recognition Memory Impairment and Oxidative-Inflammatory Response in Rats with an Intrahippocampal Injection of Amyloid Beta 1–42
- Source :
- Oxidative Medicine and Cellular Longevity, Oxidative Medicine and Cellular Longevity, Vol 2018 (2018)
- Publication Year :
- 2018
- Publisher :
- Hindawi Limited, 2018.
-
Abstract
- An important worldwide health problem as the result of current lifestyle is metabolic syndrome (MS). It has been shown that MS induced by a high-calorie diet (HCD) in rats produces cognitive deterioration in the novel object recognition test (NORt) and decreases synaptic connections and dendritic order in the hippocampus and temporal cortex. However, it is unknown whether MS induced by an HCD participates in the cognitive process observed with the injection of Aβ1–42 into the hippocampus of rats as a model of Alzheimer disease (AD). The induction of MS in rats produces a deterioration in NORt; however, rats with MS injected with Aβ1–42 show a major deterioration in the cognitive process. This event could be explained by the increment in the oxidative stress in both cases studied (MS and Aβ1–42): together, the hippocampus and temporal cortex produce an enhancer effect. In the same way, we observed an increment in interleukin-1β, TNF-α, and GFAP, indicative of exacerbated inflammatory processes by the combination of MS and Aβ1–42. We can conclude that MS might play a key role in the apparition and development of cognitive disorders, including AD. We propose that metabolic theory is important to explain the apparition of cognitive diseases.
- Subjects :
- Male
0301 basic medicine
Aging
Article Subject
Amyloid beta
Hippocampus
medicine.disease_cause
Biochemistry
03 medical and health sciences
0302 clinical medicine
medicine
Animals
lcsh:QH573-671
Rats, Wistar
Recognition memory
Inflammation
Metabolic Syndrome
Temporal cortex
Memory Disorders
Amyloid beta-Peptides
biology
lcsh:Cytology
business.industry
Cognition
Cell Biology
General Medicine
medicine.disease
Rats
Disease Models, Animal
Oxidative Stress
030104 developmental biology
biology.protein
Alzheimer's disease
Metabolic syndrome
business
Neuroscience
030217 neurology & neurosurgery
Oxidative stress
Research Article
Subjects
Details
- ISSN :
- 19420994 and 19420900
- Volume :
- 2018
- Database :
- OpenAIRE
- Journal :
- Oxidative Medicine and Cellular Longevity
- Accession number :
- edsair.doi.dedup.....791b7952acb93433196d0b25b29e9412