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High-phytate/low-calcium diet is a risk factor for crystal nephropathies, renal phosphate wasting, and bone loss
- Source :
- eLife, eLife, Vol 9 (2020)
- Publication Year :
- 2020
- Publisher :
- eLife Sciences Publications, Ltd, 2020.
-
Abstract
- Phosphate overload contributes to mineral bone disorders that are associated with crystal nephropathies. Phytate, the major form of phosphorus in plant seeds, is known as an indigestible and of negligible nutritional value in humans. However, the mechanism and adverse effects of high-phytate intake on Ca2+and phosphate absorption and homeostasis are unknown. Here, we show that excessive intake of phytate along with a low-Ca2+diet fed to rats contributed to the development of crystal nephropathies, renal phosphate wasting, and bone loss through tubular dysfunction secondary to dysregulation of intestinal calcium and phosphate absorption. Moreover, Ca2+supplementation alleviated the detrimental effects of excess dietary phytate on bone and kidney through excretion of undigested Ca2+-phytate, which prevented a vicious cycle of intestinal phosphate overload and renal phosphate wasting while improving intestinal Ca2+bioavailability. Thus, we demonstrate that phytate is digestible without a high-Ca2+diet and is a risk factor for phosphate overloading and for the development of crystal nephropathies and bone disease.
- Subjects :
- 0301 basic medicine
Male
Bone disease
kidney stones
030232 urology & nephrology
Rats, Sprague-Dawley
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
phytate
Biology (General)
Kidney
Minerals
General Neuroscience
Phosphorus
General Medicine
medicine.anatomical_structure
Medicine
Female
Hypophosphatemia
Research Article
medicine.medical_specialty
Phytic Acid
QH301-705.5
Science
chemistry.chemical_element
phosphate overload
Calcium
General Biochemistry, Genetics and Molecular Biology
Bone and Bones
Phosphates
Excretion
03 medical and health sciences
Internal medicine
medicine
Animals
Renal Insufficiency, Chronic
Human Biology and Medicine
hypophosphatemia
calcium
General Immunology and Microbiology
medicine.disease
Phosphate
Animal Feed
Diet
Calcium, Dietary
030104 developmental biology
Endocrinology
chemistry
Rat
Homeostasis
crystal nephropathies
Subjects
Details
- Language :
- English
- ISSN :
- 2050084X
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- eLife
- Accession number :
- edsair.doi.dedup.....791ab4aaf10f761446a7dab7eb202961