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High-phytate/low-calcium diet is a risk factor for crystal nephropathies, renal phosphate wasting, and bone loss

Authors :
Cheolsoo Choi
Yun Shin Jung
June Hur
Hyung Jin Choi
Carmen J. Booth
Sun Wook Cho
Ji-Young Cha
Joong Hyuck Auh
Woo Jin Jung
Yun-Jae Jung
Young Jae Lee
Jun Young Yang
Cheol Soon Lee
Dae Ho Lee
Byung-Chul Oh
Jung-Wan Kim
Ok Hee Kim
Jinwook Lee
Young Joo Park
Young-Bum Kim
Hyeonjin Kim
Seung Soon Im
Kyong Soo Park
Han Seok Choi
Jin Ku Kang
Source :
eLife, eLife, Vol 9 (2020)
Publication Year :
2020
Publisher :
eLife Sciences Publications, Ltd, 2020.

Abstract

Phosphate overload contributes to mineral bone disorders that are associated with crystal nephropathies. Phytate, the major form of phosphorus in plant seeds, is known as an indigestible and of negligible nutritional value in humans. However, the mechanism and adverse effects of high-phytate intake on Ca2+and phosphate absorption and homeostasis are unknown. Here, we show that excessive intake of phytate along with a low-Ca2+diet fed to rats contributed to the development of crystal nephropathies, renal phosphate wasting, and bone loss through tubular dysfunction secondary to dysregulation of intestinal calcium and phosphate absorption. Moreover, Ca2+supplementation alleviated the detrimental effects of excess dietary phytate on bone and kidney through excretion of undigested Ca2+-phytate, which prevented a vicious cycle of intestinal phosphate overload and renal phosphate wasting while improving intestinal Ca2+bioavailability. Thus, we demonstrate that phytate is digestible without a high-Ca2+diet and is a risk factor for phosphate overloading and for the development of crystal nephropathies and bone disease.

Details

Language :
English
ISSN :
2050084X
Volume :
9
Database :
OpenAIRE
Journal :
eLife
Accession number :
edsair.doi.dedup.....791ab4aaf10f761446a7dab7eb202961