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Properties of fatty acids in dispersions of emulsified lipid and bile salt and the significance of these properties in fat absorption in the pig and the sheep
- Source :
- British Journal of Nutrition. 23:249-263
- Publication Year :
- 1969
- Publisher :
- Cambridge University Press (CUP), 1969.
-
Abstract
- 1. The behaviour of fatty acids in dilute bile salt solution and in dispersions of triglyceride in bile salt solution was examined. The properties of fatty acids in bile salt solution were defined in terms of their saturation ratio, and of the critical micellar concentration of bile salt for each fatty acid as solute. The partition of fatty acids between the oil phase and the micellar phase of the dispersions was defined as the distribution coefficientK M/O.The phases were separated by ultracentrifugation.2. Of the fatty acids examined, palmitic and stearic acids behaved in bile salt solution as typical non-polar solutes. Lauric, oleic and linoleic acids had properties similar to typical amphiphiles. The effectiveness of these and other amphiphiles was expressed in terms of an amphiphilic index.3. Thetrans-fatty acids, vaccenic acid and linolelaidic acid possessed solubility properties similar to theircis-isomers. The properties of elaidic acid were intermediate between those of the non-polar and the amphiphilic solutes.4. The distribution coefficients of fatty acids differed less significantly than their solubilities in bile salt solution, but were influenced to some extent by the composition of the oil phase.5. The effect of pH on the partition of fatty acids was similar for all fatty acids examined. There was a marked increase in the partition of fatty acids in the micellar phase as pH increased above 6.2.6. In the presence of Ca2+ions above a threshold concentration of I m-equiv./l. and at a pH higher than 6.4, the partition of stearic acid in the micellar phase of the bi-phasic system was restricted. No interaction of Ca2+ion and pH was observed with oleic acid.7. The effect of some amphiphiles on the distribution coefficient of stearic acid was examined. The capacity of lysolecithin to solubilize stearic acid in the micellar phase of dispersions was about twice that of I-mono-olein. The significance of the results in relation to fat absorption in the pig and the sheep is discussed.
- Subjects :
- Chemical Phenomena
Swine
Linoleic acid
Medicine (miscellaneous)
Vaccenic acid
Tritium
Bile Acids and Salts
chemistry.chemical_compound
Animals
Triglycerides
chemistry.chemical_classification
Carbon Isotopes
Sheep
Nutrition and Dietetics
Chromatography
Triglyceride
Fatty Acids
Fatty acid
Hydrogen-Ion Concentration
Lipid Metabolism
Elaidic acid
Molecular Weight
Chemistry
Linolelaidic acid
Intestinal Absorption
Solubility
chemistry
Biochemistry
Calcium
Emulsions
lipids (amino acids, peptides, and proteins)
Stearic acid
Polyunsaturated fatty acid
Subjects
Details
- ISSN :
- 14752662 and 00071145
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- British Journal of Nutrition
- Accession number :
- edsair.doi.dedup.....791a32aae3b5b652fdd39b9b82b93ec5
- Full Text :
- https://doi.org/10.1079/bjn19690032