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Fetal pancreatic β-cell function in pregnancies complicated by maternal diabetes mellitus: Relationship to fetal acidemia and macrosomia
- Source :
- American Journal of Obstetrics and Gynecology. 168:1363-1369
- Publication Year :
- 1993
- Publisher :
- Elsevier BV, 1993.
-
Abstract
- Our purpose was to investigate the relationship between fetal pancreatic beta-cell function and fetal acidemia and macrosomia in pregnancies complicated by maternal diabetes mellitus.A cross-sectional study at the Harris Birthright Research Centre for Fetal Medicine, London, was performed. In 32 pregnancies complicated by maternal diabetes mellitus cordocentesis was performed at 36 to 39 weeks' gestation for the measurement of umbilical venous blood pH, PO2, PCO2, lactate, and glucose concentration; plasma insulin immunoreactivity; and insulin/glucose ratio. A reference range for plasma insulin and insulin/glucose ratio was constructed by studying fetal blood samples from 80 women who did not have diabetes mellitus.Mean umbilical venous blood pH was significantly lower and plasma insulin immunoreactivity and insulin/glucose ratio were significantly higher than the appropriate normal mean for gestation. There were significant associations between (1) maternal and fetal blood glucose concentrations (r = 0.95, p0.0001), (2) fetal blood glucose and plasma insulin immunoreactivity (r = 0.57, p0.01), (3) fetal plasma insulin immunoreactivity and blood pH (r = -0.39, p0.05), and (4) fetal insulin/glucose ratio and degree of macrosomia (r = 0.76, p0.0001).Fetal pancreatic beta-cell hyperplasia is implicated in the pathogenesis of both fetal acidemia and macrosomia.
- Subjects :
- Blood Glucose
medicine.medical_specialty
medicine.medical_treatment
Pregnancy in Diabetics
Fetal Macrosomia
Islets of Langerhans
Fetus
Pregnancy
Internal medicine
Diabetes mellitus
medicine
Humans
Insulin
Pancreatic hormone
business.industry
Infant, Newborn
Obstetrics and Gynecology
Venous blood
Hydrogen-Ion Concentration
Fetal Blood
medicine.disease
Hypoglycemia
Diabetes, Gestational
Cross-Sectional Studies
Endocrinology
medicine.anatomical_structure
Gestation
Female
Acidosis
business
Pancreas
Subjects
Details
- ISSN :
- 00029378
- Volume :
- 168
- Database :
- OpenAIRE
- Journal :
- American Journal of Obstetrics and Gynecology
- Accession number :
- edsair.doi.dedup.....79197667cb31dda32bcebd1a00c031aa