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Elevated Numbers of CD163+ Macrophages in Hearts of Simian Immunodeficiency Virus-Infected Monkeys Correlate with Cardiac Pathology and Fibrosis
- Source :
- AIDS Research and Human Retroviruses. 30:685-694
- Publication Year :
- 2014
- Publisher :
- Mary Ann Liebert Inc, 2014.
-
Abstract
- The role of macrophage activation, traffic, and accumulation on cardiac pathology was examined in 23 animals. Seventeen animals were simian immunodeficiency virus (SIV) infected, 12 were CD8 lymphocyte depleted, and the remaining six were uninfected controls (two CD8 lymphocyte depleted, four nondepleted). None of the uninfected controls had cardiac pathology. One of five (20%) SIV-infected, non-CD8 lymphocyte-depleted animals had minor cardiac pathology with increased numbers of macrophages in ventricular tissue compared to controls. Seven of the 12 (58%) SIV-infected, CD8 lymphocyte-depleted animals had cardiac pathology in ventricular tissues, including macrophage infiltration and myocardial degeneration. The extent of fibrosis (measured as the percentage of collagen per tissue area) was increased 41% in SIV-infected, CD8 lymphocyte-depleted animals with cardiac pathology compared to animals without pathological abnormalities. The number of CD163+ macrophages increased significantly in SIV-infected, CD8 lymphocyte-depleted animals with cardiac pathology compared to ones without pathology (1.66-fold) and controls (5.42-fold). The percent of collagen (percentage of collagen per total tissue area) positively correlated with macrophage numbers in ventricular tissue in SIV-infected animals. There was an increase of BrdU+ monocytes in the heart during late SIV infection, regardless of pathology. These data implicate monocyte/macrophage activation and accumulation in the development of cardiac pathology with SIV infection.
- Subjects :
- Pathology
medicine.medical_specialty
Myocarditis
Heart Ventricles
Lymphocyte
Immunology
Simian Acquired Immunodeficiency Syndrome
Antigens, Differentiation, Myelomonocytic
Receptors, Cell Surface
Pathogenesis
CD8-Positive T-Lymphocytes
Biology
medicine.disease_cause
Lymphocyte Depletion
Monocytes
Antigens, CD
Fibrosis
Virology
medicine
Animals
Macrophage
Retrospective Studies
Macrophages
Myocardium
Monocyte
Macrophage Activation
Viral Load
Simian immunodeficiency virus
medicine.disease
Macaca mulatta
Infectious Diseases
medicine.anatomical_structure
Bromodeoxyuridine
RNA, Viral
Simian Immunodeficiency Virus
Viral Fusion Proteins
CD163
CD8
Subjects
Details
- ISSN :
- 19318405 and 08892229
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- AIDS Research and Human Retroviruses
- Accession number :
- edsair.doi.dedup.....790fad489e873464aef9305cf284c12b