Back to Search
Start Over
Environmental contamination in a high-income country (France) by antibiotics, antibiotic-resistant bacteria, and antibiotic resistance genes: Status and possible causes
- Source :
- Environment International, Environment International, 2022, 159, pp.107047. ⟨10.1016/j.envint.2021.107047⟩, Environment International, Elsevier, 2022, 159, pp.107047. ⟨10.1016/j.envint.2021.107047⟩, Environment International, Vol 159, Iss, Pp 107047-(2022)
- Publication Year :
- 2022
- Publisher :
- HAL CCSD, 2022.
-
Abstract
- This document was prepared thanks to the collective expert assessment, carried out by the Anses expert working group ‘Antimicrobial resistance and the environment’ (ANSES opinion 2016-SA-0252), chaired by Morgane Bachelot and whose active contributors are co-authors of this publication.; International audience; Antimicrobial resistance (AMR) is a major global public health concern, shared by a large number of human and animal health actors. Within the framework of a One Health approach, actions should be implemented in the environmental realm, as well as the human and animal realms. The Government of France commissioned a report to provide policy and decision makers with an evidential basis for recommending or taking future actions to mitigate AMR in the environment. We first examined the mechanisms that underlie the emergence and persistence of antimicrobial resistance in the environment. This report drew up an inventory of the contamination of aquatic and terrestrial environments by AMR and antibiotics, anticipating that the findings will be representative of some other high-income countries. Effluents of wastewater treatment plants were identified as the major source of contamination on French territory, with spreading of organic waste products as a more diffuse and incidental contamination of aquatic environments. A limitation of this review is the heterogeneity of available data in space and time, as well as the lack of data for certain sources.Comparing the French Measured Environmental Concentrations (MECs) with predicted no effect concentrations (PNECs), fluoroquinolones and trimethoprim were identified as representing high and medium risk of favoring the selection of resistant bacteria in treated wastewater and in the most contaminated rivers. All other antibiotic molecules analyzed (erythromycin, clarithromycin, azithromycin, tetracycline) were at low risk of resistance selection in those environments. However, the heterogeneity of the data available impairs their full exploitation. Consequently, we listed indicators to survey AMR and antibiotics in the environment and recommended the harmonization of sampling strategies and endpoints for analyses.Finally, the objectives and methods used for the present work could comprise a useful example for how national authorities of countries sharing common socio-geographic characteristics with France could seek to better understand and define the environmental dimension of AMR in their particular settings.
- Subjects :
- [SDE] Environmental Sciences
MESH: Drug Resistance, Microbial
Antibiotic resistance
MESH: One Health
010501 environmental sciences
Wastewater
01 natural sciences
MESH: Waste Water
03 medical and health sciences
Rivers
MESH: Anti-Bacterial Agents
Drug Resistance, Bacterial
Animals
GE1-350
One Health
030304 developmental biology
0105 earth and related environmental sciences
General Environmental Science
Environmental antibiotic concentrations
0303 health sciences
Bacteria
Aquatic environment
[SDV.EE.IEO] Life Sciences [q-bio]/Ecology, environment/Symbiosis
6. Clean water
Anti-Bacterial Agents
3. Good health
Environmental sciences
[SDE.BE] Environmental Sciences/Biodiversity and Ecology
Terrestrial environment
13. Climate action
[SDE]Environmental Sciences
Organic waste product
[SDE.BE]Environmental Sciences/Biodiversity and Ecology
[CHIM.OTHE]Chemical Sciences/Other
[SDV.EE.IEO]Life Sciences [q-bio]/Ecology, environment/Symbiosis
Subjects
Details
- Language :
- English
- ISSN :
- 01604120
- Database :
- OpenAIRE
- Journal :
- Environment International, Environment International, 2022, 159, pp.107047. ⟨10.1016/j.envint.2021.107047⟩, Environment International, Elsevier, 2022, 159, pp.107047. ⟨10.1016/j.envint.2021.107047⟩, Environment International, Vol 159, Iss, Pp 107047-(2022)
- Accession number :
- edsair.doi.dedup.....790dd59351f1a2cf9f0b09bdc8739c7e