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Effects of alcohol on TMS-evoked N100 responses
- Source :
- Journal of neuroscience methods. 166(1)
- Publication Year :
- 2006
-
Abstract
- TMS combined with simultaneous EEG is a novel brain imaging tool allowing investigation local excitability of human cortex. As alcohol acts through increasing function of A-type gamma-aminobutyric acid receptors and attenuating the function of glutaminergic NMDA-receptors-related excitation, we tested whether TMS-evoked N100 response which is thought to reflect cortical inhibitory processes, might be affected by alcohol. Ten healthy subjects ingested alcohol (0.8 g/kg) and EEG responses from 60 channels before and after alcohol ingestion were recorded after left motor-cortex stimulation. Alcohol almost abolished TMS-evoked N100 response. Control experiments with a piece of plastic placed between the head and coil to exclude auditory artefacts were conducted. Alcohol effects were similar when EEG responses from control experiments were subtracted from real-TMS. Alcohol-induced decrease was similar at ipsilateral, contralateral and frontal EEG sites suggesting that alcohol may change cortico-cortical connectivity of motor cortex. Alternative explanation is that alcohol has overall suppression effect on motor cortex. N100 may provide a useful marker of neural inhibition of human cortex for drug research.
- Subjects :
- Adult
Male
Neural Inhibition
Alcohol
Stimulation
Electroencephalography
Inhibitory postsynaptic potential
chemistry.chemical_compound
Cortex (anatomy)
medicine
Reaction Time
Humans
Electrodes
Evoked Potentials
N100
Brain Mapping
medicine.diagnostic_test
Ethanol
General Neuroscience
Motor Cortex
Central Nervous System Depressants
Evoked Potentials, Motor
Receptors, GABA-A
Transcranial Magnetic Stimulation
medicine.anatomical_structure
chemistry
Psychology
Neuroscience
Biomarkers
Motor cortex
Subjects
Details
- ISSN :
- 01650270
- Volume :
- 166
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of neuroscience methods
- Accession number :
- edsair.doi.dedup.....790a07dd6a6d1aa3b8c8045f46da0ef2