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Effect of different patterns of consumption of coffee and a cocoa-based product containing coffee on the nutrikinetics and urinary excretion of phenolic compounds

Authors :
Daniele Del Rio
Monica Antonini
Alessandra Dei Cas
Letizia Bresciani
Alice Rosi
Pedro Mena
Michele Tassotti
Daniela Martini
Riccardo C. Bonadonna
Furio Brighenti
Source :
The American Journal of Clinical Nutrition. 114:2107-2118
Publication Year :
2021
Publisher :
Elsevier BV, 2021.

Abstract

BACKGROUND Coffee consumption is associated with a reduced risk of several chronic diseases in a dose-dependent manner. Chronic intake results in the transient appearance of bioactive phenolic metabolites in the circulatory system. However, there is a lack of information on the impact of different patterns of coffee consumption on plasma and urinary profiles of phenolic metabolites. OBJECTIVES Plasma and urinary phenolic metabolites were investigated following regular consumption of different daily dosages of coffee or cocoa-based products containing coffee (CBPCC) under a real-life setting. METHODS A repeated-dose, randomized, crossover human intervention was conducted with 21 healthy volunteers. For 1 mo, participants consumed 1) 1 cup of coffee (1C), 2) 3 cups of coffee (3C), or 3) 1 cup of coffee + 2 CBPCC twice daily (PC). Plasma and urine samples were collected over a 24-h period after each treatment. The nutrikinetics and urinary excretion of native, human phase II, and colonic metabolites were assessed. RESULTS A total of 51 (poly)phenolic metabolites were quantified, with 41 metabolites being strictly related to coffee consumption. Significant differences were observed among treatments for most of the metabolites. The metabolites present in the highest amounts were the hydroxycinnamate, phenylpropanoic acid, benzaldehyde, and benzene classes, along with (-)-epicatechin and phenyl-γ-valerolactone derivatives after PC treatment. Daily average concentrations did not exceed 200 nmol/L and were

Details

ISSN :
00029165
Volume :
114
Database :
OpenAIRE
Journal :
The American Journal of Clinical Nutrition
Accession number :
edsair.doi.dedup.....79021cc3b824eaa098e9e5f7de1e72e4