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Angiotensin-Converting Enzyme Gene Polymorphism in Essential Hypertensive Patients in Japanese Population
- Source :
- Angiology. 47:643-648
- Publication Year :
- 1996
- Publisher :
- SAGE Publications, 1996.
-
Abstract
- Association between angiotensin-converting enzyme (ACE) gene polymorphism and essential hypertension in a Japanese population with the same socioeconomic back ground was investigated. Insertion-deletion (I/D) polymorphism of the ACE gene located on intron 16 was detected by polymerase chain reaction. Association between ACE gene polymorphism and family history of essential hypertension as well as the development of vascular damage in eye fundi were also investigated. Variation at ACE loci did not contribute to essential hypertension and the vascular damages in eye fundi. These results suggested that the ACE gene was not directly responsible for essential hypertension in this particular Japanese population with the same socioeconomic background.
- Subjects :
- Adult
Male
medicine.medical_specialty
Molecular Sequence Data
Peptidyl-Dipeptidase A
030204 cardiovascular system & hematology
Essential hypertension
Polymerase Chain Reaction
law.invention
03 medical and health sciences
0302 clinical medicine
Japan
law
Internal medicine
Renin–angiotensin system
medicine
Humans
030212 general & internal medicine
Family history
Gene
Polymerase chain reaction
Polymorphism, Genetic
Base Sequence
biology
business.industry
Intron
Angiotensin-converting enzyme
Middle Aged
medicine.disease
eye diseases
Endocrinology
Hypertension
biology.protein
Female
Gene polymorphism
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 19401574 and 00033197
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Angiology
- Accession number :
- edsair.doi.dedup.....78fcda35db27778ca3f9b7cabbf74d06