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Severe veno-occlusive disease after autologous peripheral blood stem cell transplantation for high-grade non-Hodgkin lymphoma: report of a successfully managed case and a literature review of veno-occlusive disease
- Source :
- Clinical Transplantation. 22:837-841
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- Veno-occlusive disease (VOD) of the liver is a severe complication of high-dose chemotherapy and allogeneic or autologous stem cell transplantation with potential fatal outcome. We report a case of severe VOD in a patient with a high-grade B-cell lymphoma. Liver-venule occlusion was confirmed by liver biopsy. Supportive care, fibrinolytic treatment with recombinant tissue plasminogen activator and defibrotide maintenance therapy led to complete resolution of VOD demonstrated at liver biopsy and with a follow-up of 44 months after autologous peripheral blood stem cell transplantation. The literature on VOD has been reviewed.
- Subjects :
- Adult
Male
medicine.medical_specialty
veno occlusive disease
Lymphoma, B-Cell
Biopsy
medicine.medical_treatment
Hepatic Veno-Occlusive Disease
Hematopoietic stem cell transplantation
Defibrotide
Transplantation, Autologous
Polydeoxyribonucleotides
Autologous stem-cell transplantation
Fibrinolytic Agents
Maintenance therapy
non Hodgkin
medicine
Humans
therapy
Peripheral Blood Stem Cell Transplantation
Transplantation
Settore MED/06 - ONCOLOGIA MEDICA
stem cells transplantation
medicine.diagnostic_test
business.industry
Settore MED/09 - MEDICINA INTERNA
Aptamers, Nucleotide
medicine.disease
Lymphoma
Surgery
Settore MED/15 - MALATTIE DEL SANGUE
Tissue Plasminogen Activator
Liver biopsy
business
medicine.drug
Subjects
Details
- ISSN :
- 09020063
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Clinical Transplantation
- Accession number :
- edsair.doi.dedup.....78f38a13c9f8af9daceeea881890d474