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Greek Remdesivir Cohort (GREC) Study: Effectiveness of Antiviral Drug Remdesivir in Hospitalized Patients with COVID-19 Pneumonia

Authors :
Vasilis Petrakis
Vasiliki Rapti
Karolina Akinosoglou
Constantinos Bonelis
Kalomoira Athanasiou
Vasiliki Dimakopoulou
Nikolaos K. Syrigos
Nikolaos Spernovasilis
Grigoris Trypsianis
Markos Marangos
Charalambos Gogos
Dimitrios Papazoglou
Periklis Panagopoulos
Garyfallia Poulakou
Source :
Microorganisms; Volume 10; Issue 10; Pages: 1949
Publication Year :
2022

Abstract

In several randomized studies, remdesivir (RDV) has been reported to shorten the recovery period and improve clinical outcomes in COVID-19 patients, and thus, it is recommended as a standard of care. Nevertheless, controversial reports have been published. The aim of the present study is to evaluate the effectiveness of remdesivir in hospitalized patients with COVID-19 pneumonia at three Greek University Departments of Infectious Diseases with homogenous treatment protocols. From September 2020 to February 2021, we retrospectively analyzed adults hospitalized with confirmed SARS-CoV-2 infection and radiological findings of pneumonia, who received remdesivir once daily for five days. Exploratory end points were duration of hospitalization, time of intubation, and death. Overall, 551 patients were included in the study. The optimal cutoff point for the number of days needed after symptom initiation for drug administration associated with better clinical outcome was 7 days. Higher odds for discharge and lower for intubation were observed in patients with treatment initiation ≤7 days (p = 0.052 and p = 0.019, retrospectively) regardless of gender (p = 0.537), hypertension (p = 0.096), dyslipidemia (p = 0.221), diabetes mellitus (p = 0.306), and usage of immunomodulators (p = 0.408). Our study has demonstrated beneficial effects of early treatment with remdesivir (≤7 days from symptom onset) on rates of intubation and probability of discharge.

Details

ISSN :
20762607
Volume :
10
Issue :
10
Database :
OpenAIRE
Journal :
Microorganisms
Accession number :
edsair.doi.dedup.....78e706139423fc55a9d4202f98f1c0df