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Palmatine inhibits Zika virus infection by disrupting virus binding, entry, and stability
- Source :
- Biochemical and Biophysical Research Communications. 518:732-738
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Zika virus (ZIKV) is an emerging vector-borne virus that is associated with severe congenital cerebral anomalies in fetuses and paralytic Guillain-Barre syndrome in adults. In the current global health crisis, there are no vaccines or therapeutics available for the treatment of ZIKV infection. In the present study, we evaluated the efficacy of the protoberberine alkaloid, palmatine, in inhibiting ZIKV and Japanese encephalitis virus (JEV). Palmatine was shown to bind to restricted viruses, inhibit ZIKV infection, and resist ZIKV-induced cytopathic effects. Palmatine was also shown to inhibit JEV infection in multiple cell lines. Overall, the effects of palmatine in disrupting ZIKV binding, entry, and stability indicate that this small molecule would be a good starting point for the development of treatments aimed at inhibiting ZIKV infection.
- Subjects :
- 0301 basic medicine
viruses
Virus Binding
Berberine Alkaloids
Biophysics
Virus Attachment
Virus Replication
Biochemistry
Virus
Cell Line
Zika virus
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Cytopathogenic Effect, Viral
Chlorocebus aethiops
medicine
ZikV Infection
Animals
Humans
Vero Cells
Molecular Biology
Dose-Response Relationship, Drug
biology
Zika Virus Infection
Palmatine
Zika Virus
Cell Biology
Virus Internalization
Japanese encephalitis
biology.organism_classification
medicine.disease
Virology
030104 developmental biology
chemistry
A549 Cells
Cell culture
030220 oncology & carcinogenesis
RNA, Viral
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 518
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....78de566e63c17f8e7a182515d8a01239