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Familial hydronephrosis unlinked to the HLA complex
- Source :
- American Journal of Medical Genetics. 70:118-120
- Publication Year :
- 1997
- Publisher :
- Wiley, 1997.
-
Abstract
- Clinical findings, management, and possible linkage of congenital hydronephrosis caused by ureteropelvic junction stenosis to the HLA complex were studied in four families. These families provide evidence of possible autosomal dominant inheritance. HLA class I antigen studies in all four and class II (HLA-DR) in three families were performed. These studies failed to show close linkage to the chromosome 6 markers in two families but there was consistent inheritance in the other two. Although formal linkage calculations are not presented, it is apparent that in some families HLA haplotyping is not useful in predicting prevence of renal obstruction.
- Subjects :
- Linkage (software)
Genetics
Genetic Linkage
Histocompatibility Antigens Class I
Haplotype
Histocompatibility Antigens Class II
Infant
Ureteropelvic junction
Chromosome
Hydronephrosis
Human leukocyte antigen
Biology
Kidney
medicine.disease
Congenital hydronephrosis
Pedigree
medicine.anatomical_structure
Child, Preschool
medicine
Humans
Child
Genetics (clinical)
HLA Complex
Ureteral Obstruction
Subjects
Details
- ISSN :
- 10968628 and 01487299
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- American Journal of Medical Genetics
- Accession number :
- edsair.doi.dedup.....78ddaa82fee37efd12f77a1014018932