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Good response to pentamidine isethionate in a case of Mucosal Leishmaniasis caused by Leishmania (Viannia) braziliensis that was difficult to treat: Case Report
- Source :
- Revista da Sociedade Brasileira de Medicina Tropical, Vol 52, Iss 0 (2019)
- Publication Year :
- 2019
- Publisher :
- FapUNIFESP (SciELO), 2019.
-
Abstract
- In Brazil, meglumine antimoniate is the first drug of choice for mucosal leishmaniasis treatment followed by amphotericin B and pentamidine isethionate. We report the case of a patient with severe mucosal lesions caused by Leishmania (Viannia) braziliensis that were difficult to treat. Over a 14-year period, the patient showed low adherence and three treatment attempts with meglumine antimoniate failed. Additionally, there was an unsatisfactory response to liposomal amphotericin B and nephrotoxicity when using amphotericin B deoxycholate that persisted after new treatment attempt with liposomal amphotericin B. Finally, healing was achieved with pentamidine isethionate and maintained during nine months of monitoring.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
lcsh:Arctic medicine. Tropical medicine
Pentamidine Isethionate
lcsh:RC955-962
Meglumine antimoniate
030106 microbiology
030231 tropical medicine
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Pharmacotherapy
Internal medicine
Amphotericin B deoxycholate
Amphotericin B
medicine
biology
business.industry
Leishmaniasis
Mucosal leishmaniasis
medicine.disease
Leishmania
biology.organism_classification
Infectious Diseases
Parasitology
Therapy
Pentamidine isethionate
business
Pentamidine
medicine.drug
Subjects
Details
- ISSN :
- 16789849 and 00378682
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Revista da Sociedade Brasileira de Medicina Tropical
- Accession number :
- edsair.doi.dedup.....78cf1f071b53fe63eb1a32553d0bbf99