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Dysregulation of long non-coding RNA profile in peripheral blood of multiple sclerosis patients
- Source :
- Multiple Sclerosis and Related Disorders. 25:219-226
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Multiple sclerosis (MS) is a chronic autoimmune disorder in which dysregulation or aberrant expressions of several immune-related genes have been noted. More recently, the participation of long non-coding RNAs (lncRNAs) in regulation of immune responses has been highlighted. In the present study, we evaluated expression levels of three lncRNAs named Nuclear Paraspeckle Assembly Transcript 1 (NEAT1), P21 associated ncRNA DNA damage activated (PANDA) and Taurine-up-regulated gene 1 (TUG1) in peripheral blood of 50 relapsing-remitting MS patients and 50 matched healthy subjects. All three lncRNAs have been significantly over-expressed in MS patients compared with healthy subjects. In addition, significant correlations were found between expression levels of these three lncRNAs in the patients group. NEAT1 expression was inversely correlated with age at onset and disease duration in female patients. Moreover, TUG1 expression was inversely correlated with disease duration in female patients. The present study provides further evidences for the role of lncRNAs in pathogenesis of MS.
- Subjects :
- Adult
Male
0301 basic medicine
Multiple Sclerosis
Adolescent
Antineoplastic Agents
Pathogenesis
Young Adult
03 medical and health sciences
0302 clinical medicine
Immune system
medicine
Humans
Gene
business.industry
Multiple sclerosis
Case-control study
Bayes Theorem
Paraspeckle
General Medicine
Middle Aged
medicine.disease
Non-coding RNA
Long non-coding RNA
Up-Regulation
030104 developmental biology
ROC Curve
Neurology
Case-Control Studies
Immunology
Female
RNA, Long Noncoding
Interferons
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 22110348
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Multiple Sclerosis and Related Disorders
- Accession number :
- edsair.doi.dedup.....78ce416c3387f2e8b7aab430eb7773d1