Advances in Biomaterials for Drug Delivery

Authors :: Owen S. Fenton
Katy N. Olafson
Michael J. Mitchell
Robert Langer
Padmini S. Pillai
Massachusetts Institute of Technology. Department of Chemical Engineering
Harvard University--MIT Division of Health Sciences and Technology
Koch Institute for Integrative Cancer Research at MIT
Source :: PMC
Publication Year :: 2018
Abstract: Advances in biomaterials for drug delivery are enabling significant progress in biology and medicine. Multidisciplinary collaborations between physical scientists, engineers, biologists, and clinicians generate innovative strategies and materials to treat a range of diseases. Specifically, recent advances include major breakthroughs in materials for cancer immunotherapy, autoimmune diseases, and genome editing. Here, strategies for the design and implementation of biomaterials for drug delivery are reviewed. A brief history of the biomaterials field is first established, and then commentary on RNA delivery, responsive materials development, and immunomodulation are provided. Current challenges associated with these areas as well as opportunities to address long-standing problems in biology and medicine are discussed throughout.<br />National Institutes of Health (Award CA200351)<br />Burroughs Wellcome Fund (Grant 1015145)