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Aseptic meningitis, hepatitis and cholestasis induced by trimethoprim/sulfamethoxazole: a case report
- Source :
- BMC Pediatrics, Vol 21, Iss 1, Pp 1-4 (2021), BMC Pediatrics
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- BackgroundDrug-induced aseptic meningitis is a rare, but challenging diagnosis, most commonly reported with nonsteoroidal anti-inflammatory drugs (NSAIDs) and antibiotics. Trimethoprim/sulfamethoxazole (TMP/SMX) is a sulfonamide that is widely used in clinical practice for the treatment and prophylaxis of various infections. The most common side effects associated with TMP/SMX are generally mild and self-limited, but serious side effects have been reported, including liver injury and aseptic meningitis.Case presentationWe report a 2,5 year old Dutch girl with both drug-induced aseptic meningitis and drug-induced liver injury while using TMP/SMX prophylaxis. Ursodeoxycholic acid was started because of cholestatic injury. After cessation of TMP/SMX, full convalescence was reached within weeks.ConclusionsThis is the first report of a young patient with both aseptic meningitis and drug-induced liver injury caused by TMP/SMX. Drug-induced aseptic meningitis and cholestatic hepatitis constitute a considerable diagnostic challenge to clinicians. In addition to a thorough evaluation for infectious causes, clinicians should be aware of drug-induced aseptic meningitis and cholestatic hepatitis.
- Subjects :
- medicine.medical_specialty
medicine.drug_class
media_common.quotation_subject
Antibiotics
urologic and male genital diseases
Pediatrics
RJ1-570
Hepatitis
Aseptic meningitis
Cholestasis
Anti-Infective Agents
Internal medicine
Trimethoprim, Sulfamethoxazole Drug Combination
Case report
Medicine
Humans
Meningitis, Aseptic
media_common
Trimethoprim-sulfamethoxazole
business.industry
Convalescence
Sulfamethoxazole
Sulfonamide (medicine)
Drug-induced
medicine.disease
bacterial infections and mycoses
Trimethoprim
female genital diseases and pregnancy complications
Child, Preschool
Pediatrics, Perinatology and Child Health
Female
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 14712431
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Pediatrics
- Accession number :
- edsair.doi.dedup.....78b278d19104ec18017fdb45ffeef0ba