MannosylGlycodendritic Structure Inhibits DC-SIGN-Mediated Ebola VirusInfection in cis and in trans

Authors :: Javier Rojo
Rafael Delgado
Joaquín R. Otero
Fátima Lasala
Eva Arce
Source :: Digital.CSIC. Repositorio Institucional del CSIC, instname
Publication Year :: 2003
Publisher :: American Society for Microbiology, 2003.
Abstract: 3 páginas, 3 figuras.<br />We have designed a glycodendritic structure, BH30sucMan, that blocks the interaction between dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and Ebola virus (EBOV) envelope. BH30sucMan inhibits DC-SIGN-mediated EBOV infection at nanomolar concentrations. BH30sucMan may counteract important steps of the infective process of EBOV and, potentially, of microorganisms shown to exploit DC-SIGN for cell entry and infection.<br />This research was supported by DGI grant no. BQU2002-03734 to J.R. and grants FIS 01/1430 and FIPSE 3026/99 to R.D.

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