Back to Search
Start Over
Effect of Arginine Infusion on Ghrelin Secretion in Growth Hormone-Sufficient and GH-Deficient Children
- Source :
- International Journal of Endocrinology and Metabolism
- Publication Year :
- 2012
- Publisher :
- Briefland, 2012.
-
Abstract
- Background The physiological link between ghrelin and growth hormone (GH) has not yet been fully clarified. Furthermore, the existence of a negative feedback mechanism between growth hormone–insulin-like growth factor (GH–IGF)-I axis and ghrelin and the influence of amino acids on ghrelin secretion in children remain matters of debate. Objectives To understand the regulation of ghrelin secretion and clarify the relationship between ghrelin and GH secretion in GH-deficient (GHD) and GH-sufficient (GHS) children. Patients and Methods Ten GHD (male/female [M/F], 6/4; age [mean ± SEM], 10.7 ± 0.9 years) and 10 GHS prepubertal children (M/F, 6/4; age [mean ± SEM], 10.3 ± 0.6 years), underwent an arginine (ARG) test (infusion, 0.5 g/kg, iv). Levels of GH, total ghrelin, and acylated ghrelin (AG) were assayed every 30 min from 0 to +120 min. Results Peak GH values were lower in GHD subjects than in GHS subjects (P < 0.0001). The baseline levels, peak levels, or area under the curves (AUC) for total ghrelin and AG were similar between GHD and GHS children. ARG infusion was followed by a slight to significant decrease in total ghrelin levels, but not AG levels, both in GHD and GHS subjects with a nadir at +30 min. No correlation was seen between GH, total ghrelin, or AG response and ARG infusion. Conclusions Total ghrelin and AG levels seemed unaffected by GH status in prepubertal children. ARG infusion was unable to blunt ghrelin secretion irrespective of GH status in childhood. Moreover, since ARG influences GH secretion via modulation of somatostatin release, ghrelin secretion seems to be partially refractory to somatostatin action.
- Subjects :
- medicine.medical_specialty
Arginine
business.industry
Acylated Ghrelin
Endocrinology, Diabetes and Metabolism
Growth factor
medicine.medical_treatment
digestive, oral, and skin physiology
medicine.disease
Growth hormone
Growth hormone secretion
Growth hormone deficiency
Endocrinology
Somatostatin
Growth Hormone Deficiency
Growth Hormone
Internal medicine
medicine
Original Article
Ghrelin
business
hormones, hormone substitutes, and hormone antagonists
Ghrelin secretion
Subjects
Details
- ISSN :
- 17269148 and 1726913X
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- International Journal of Endocrinology and Metabolism
- Accession number :
- edsair.doi.dedup.....78a6eadf4eb56e05b101c0a8d7452749