Glyburide and Glipizide in Treatment of Diabetic Patients With Secondary Failures to Tolazamide or Chlorpropamid

We evaluated therapeutic usefulness of the second-generation sulfonylurea agents glyburide and glipizide in non-insulin-dependent diabetic patients who were secondary failures on chlorpropamide or tolazamide. Twenty patients were treated with glyburide, and 10 of them were subsequently treated with glipizide. Fasting and postprandial serum glucose, insulin, C-peptide, glycosylated hemoglobin, urinary C-peptide, and glucose levels all failed to show significant improvement. We conclude that both glyburide and glipizide proved ineffective in the treatment of secondary failures to first-generation sulfonylureas.