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Deep learning with ultrasonography: automated classification of liver fibrosis using a deep convolutional neural network
- Source :
- European radiology. 30(2)
- Publication Year :
- 2019
-
Abstract
- The aim of this study was to develop a deep convolutional neural network (DCNN) for the prediction of the METAVIR score using B-mode ultrasonography images. Datasets from two tertiary academic referral centers were used. A total of 13,608 ultrasonography images from 3446 patients who underwent surgical resection, biopsy, or transient elastography were used for training a DCNN for the prediction of the METAVIR score. Pathological specimens or estimated METAVIR scores derived from transient elastography were used as a reference standard. A four-class model (F0 vs. F1 vs. F23 vs. F4) was developed. Diagnostic performance of the algorithm was validated on a separate internal test set of 266 patients with 300 images and external test set of 572 patients with 1232 images. Performance in classification of cirrhosis was compared between the DCNN and five radiologists. The accuracy of the four-class model was 83.5% and 76.4% on the internal and external test set, respectively. The area under the receiver operating characteristic curve (AUC) for classification of cirrhosis (F4) was 0.901 (95% confidence interval [CI], 0.865–0.937) on the internal test set and 0.857 (95% CI, 0.825–0.889) on the external test set, respectively. The AUC of the DCNN for classification of cirrhosis (0.857) was significantly higher than that of all five radiologists (AUC range, 0.656–0.816; p value
- Subjects :
- Liver Cirrhosis
Male
medicine.medical_specialty
Cirrhosis
Convolutional neural network
Deep Learning
Radiologists
medicine
Humans
Radiology, Nuclear Medicine and imaging
Neuroradiology
Retrospective Studies
Ultrasonography
Receiver operating characteristic
business.industry
Deep learning
Reproducibility of Results
General Medicine
Middle Aged
medicine.disease
Confidence interval
ROC Curve
Test set
Elasticity Imaging Techniques
Female
Radiology
Artificial intelligence
Clinical Competence
Transient elastography
business
Algorithms
Subjects
Details
- ISSN :
- 14321084
- Volume :
- 30
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- European radiology
- Accession number :
- edsair.doi.dedup.....789167748b9d6d12c9b3e66303f11b98